BRCA2 hereditary breast and ovarian cancer syndrome

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Other Names: BRCA2 Hereditary Breast and Ovarian Cancer; Breast cancer, familial 2, BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2, INCLUDED, BROVCA2, Breast-ovarian cancer, familial 2, Familial susceptibility to breast-ovarian cancer 2, HBOC, Hereditary breast and ovarian cancer syndrome, OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2, INCLUDED See more

Categories: Congenital and Genetic Diseases, Female Reproductive Diseases, Hereditary Cancer Syndromes, Rare Cancers

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BRCA2 hereditary breast and ovarian cancer syndrome ( BRCA2 HBOC) is an inherited condition that is characterized by an increased risk for a variety of different cancers. Women with this condition have a 49-55% risk of developing breast cancer, a 16-18% risk of developing ovarian cancer and a 62% risk of developing contralateral breast cancer by age 70. Men have a 6% lifetime risk of breast cancer and an increased risk for prostate cancer. Both men and women with BRCA2 HBOC have an elevated risk for pancreatic cancer. BRCA2 HBOC may also be associated with cancers of the stomach, gallbladder, bile duct, esophagus, stomach, fallopian tube, primary peritoneum, and skin; however, these risks are not well defined. This condition is caused by changes (mutations) in the BRCA2 gene and is inherited in an autosomal dominant manner. Management may include high risk cancer screening, chemopreventation and/or prophylactic surgeries.

Source: GARD Last updated on 05-01-20

Symptoms

Symptoms and their Known Frequencies

80%-99% of people have these symptoms.

Click on a symptom to see definitions for associated terms.

Photomyoclonic seizures
Primary peritoneal carcinoma
Abnormality of the fallopian tube
Coronary artery stenosis
Abnormal fallopian tube morphology
Ovarian neoplasm

30%-79% of people have these symptoms.

Click on a symptom to see definitions for associated terms.

Breast carcinoma

5%-29% of people have these symptoms.

Click on a symptom to see definitions for associated terms.

Prostate cancer
Neoplasm of the pancreas
Melanoma

An unknown % of people have these symptoms.

Click on a symptom to see definitions for associated terms.

Prominence of the premaxilla
Midshaft hypospadias
Ebstein anomaly of the tricuspid valve
Primary peritoneal carcinoma
Breast carcinoma
Neoplasm of the pancreas
Prostate cancer

In-Depth Information

MD Anderson

MD Anderson Cancer Center offers a free online course on BRCA2 hereditary breast and ovarian cancer syndrome. Click on the link to access this course.

Last updated on 04-27-20

Name: American Cancer Society 250 Williams Street NW
Atlanta, GA, 30329, United States Toll Free: 1-800-227-2345 Url: https://www.cancer.org

Name: Ovarian Cancer Research Alliance 14 Pennsylvania Plaza, Suite 2110
New York, NY, 10122, United States Phone: 212-268-1002 Toll Free: 866-399-6262 Fax : 202-331-2292 Email: info@ocrahope.org Url: https://ocrahope.org

Name: National Ovarian Cancer Coalition 2501 Oak Lawn Avenue, Suite 435
Dallas, TX, 75219 , United States Phone: 214-273-4200 Toll Free: 888-OVARIAN Fax : 214-273-4201 Email: nocc@ovarian.org Url: http://www.ovarian.org/

Name: The National Breast Cancer Coalition/Fund 1101 17th Street Northwest Suite 1300
Washington, DC, 20036 , United States Phone: 202-296-7477 Toll Free: 800-622-2838 Fax : 202-265-6854 Url: http://www.stopbreastcancer.org/

Name: The Susan G. Komen Breast Cancer Foundation 5005 LBJ Freeway Suite 250
Dallas, TX, 75244, United States Phone: 972-855-1600 Toll Free: 877-465-6636 Fax : 972-855-1605 Email: helpline@komen.org Url: http://ww5.komen.org/

Name: FORCE: Facing Our Risk of Cancer Empowered 16057 Tampa Palms Blvd. W, PMB #373
Tampa, FL, 33647, Toll Free: 866-288-RISK (7475) Fax : 954-827-2200 Email: info@facingourrisk.org Url: http://www.facingourrisk.org

Name: Bright Pink 670 N. Clark St., Suite 2
Chicago, IL, 60654, Url: http://www.brightpink.org

Name: Minnesota Ovarian Cancer Alliance 4604 Chicago Ave
Minneapolis, MN, 55407, Phone: 612-822-0500 Email: INFO@MNOVARIAN.ORG Url: http://mnovarian.org/

Petrucelli N, Daly MB & Feldman GL. BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer GeneReviews. September 26, 2013; Reference Link Ana Rath and Stéphanie NGUENGANG WAKAP. Prevalence of rare diseases: Bibliographic data », Orphanet Report Series, Rare Diseases collection, January 2020, Number 2 : Diseases listed by decreasing prevalence, incidence or number of published cases Orphanet Report Series - Prevalence of rare diseases: Bibliographic data - January 2020 - Number 2. January 2020; Number 2. 64. Reference Link Orphanet Reference Link

Note, these links are external searches against the National Laboratory of Medicine's drug database. You may need to adjust the search if there are no results found.

Drug Name	Generic Name
Lynparza	olaparib

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BRCA2 hereditary breast and ovarian cancer syndrome

Table of Contents

Don’t fight BRCA2 hereditary breast and ovarian cancer syndrome alone.

Symptoms

Symptoms and their Known Frequencies

In-Depth Information

MD Anderson

Connect with other users with BRCA2 hereditary breast and ovarian cancer syndrome on the RareGuru app

Join the RareGuru Community

BRCA2 hereditary breast and ovarian cancer syndrome

Table of Contents

Don’t fight BRCA2 hereditary breast and ovarian cancer syndrome alone.

Symptoms

Symptoms and their Known Frequencies

Resources

In-Depth Information

MD Anderson

Organizations

References

Orphan Drugs

Connect with other users with BRCA2 hereditary breast and ovarian cancer syndrome on the RareGuru app

Join the RareGuru Community