Abdominal aortic aneurysm

Is abdominal aortic aneurysm inherited?

Abdominal aortic aneurysm (AAA) is thought to be a multifactorial condition, meaning that one or more genes likely interact with environmental factors to cause the condition. In some cases, it may occur as part of an inherited syndrome.

Having a family history of AAA increases the risk of developing the condition. A genetic predisposition has been suspected since the first report of three brothers who had a ruptured AAA, and additional families with multiple affected relatives have been reported. In some cases, it may be referred to as " familial abdominal aortic aneurysm." A Swedish survey reported that the relative risk of developing AAA for a first-degree relative of a person with AAA was approximately double that of a person with no family history of AAA. In another study, having a family history increased the risk of having an aneurysm 4.3-fold. The highest risk was among brothers older than age 60, in whom the prevalence was 18%.

While specific variations in DNA (polymorphisms) are known or suspected to increase the risk for AAA, no one gene is known to cause isolated AAA. It can occur with some inherited disorders that are caused by mutations in a single gene, such as Marfan syndrome and Ehlers-Danlos syndrome, vascular type. However, these more typically involve the thoracoabdominal aorta.

Because the inheritance of AAA is complex, it is not possible to predict whether a specific person will develop AAA. People interested in learning more about the genetics of AAA, and how their family history affects risks to specific family members, should speak with a genetics professional.

Last updated on 05-01-20

Management Guidelines

The Society of Interventional Radiology - Abdominal aortic aneurysm

The Society of Interventional Radiology provides information about the management of abdominal aortic aneurysm. Click on the link above to access this information.

Last updated on 04-27-20

Selected Full-Text Journal Articles

American Family Physician - Abdominal aortic aneurysm

The American Family Physician provides an online journal article about abdominal aortic aneurysm. Click on the link above to access this article.

Last updated on 04-27-20

Name: The Marfan Foundation 22 Manhasset Avenue
Port Washington, NY, 11050 , United States
Phone: +1-516-883-8712 Toll Free: 1-800-8-MARFAN (800-862-7326) Fax : +1-516-883-8040 Email: https://www.marfan.org/secure/ask Url: https://www.marfan.org/
Name: American Heart Association 7272 Greenville Avenue
Dallas, TX, 75231-4596, United States
Phone: 214-570-5978 Toll Free: 800-242-8721 Email: https://www.heart.org/en/forms/general-questions-and-latest-research-information Url: https://www.heart.org
Name: The John Ritter Foundation for Aortic Health 11901 Santa Monica Blvd. #410
Los Angeles, CA, 90025,
Phone: 310-736-1550 Email: http://johnritterfoundation.org/contact/ Url: http://johnritterfoundation.org/

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