What causes syndactyly?

During normal embryonic (fetal) development, the hand initially forms in the shape of a paddle, and then eventually splits into separate fingers. Syndactyly results when one or more fingers fail to separate during this time.

Research continues into further understanding why this happens. Many cases seem to occur without an apparent cause, while some may occur due to a genetic (inherited) defect, environmental exposure during pregnancy, or a combination or both factors. Syndactyly may also occur as a part of an underlying genetic syndrome and can be found in over 300 different genetic syndromes.

Last updated on 05-01-20

Where To Start

Children's Hospital of Philadelphia

The Children's Hospital of Philadelphia offers information on Syndactyly.

Last updated on 04-27-20

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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