Selective IgA deficiency

Selective IgA deficiency is the most common type of primary immunodeficiency syndrome. Individuals with this condition have a complete absence or severe deficiency of IgA, which is essential in the respiratory and gastrointestinal tracts and plays a role in developing mucosal immunity and protection against infection. While many people with selective IgA deficiency appear healthy, they are more prone to infections, allergies, diarrhea, and autoimmune diseases. The underlying cause of selective IgA deficiency is unknown. Familial occurrence has been reported, with some cases suggestive of autosomal dominant inheritance and others of autosomal recessive inheritance. At this time, there is no way to replace IgA in the body. Antibiotics may be used to treat infections or prevent new infections from occurring.