Myalgic encephalomyelitis

Myalgic encephalomyelitis (ME) is defined by distinctive neuro-muscular symptoms: prolonged muscle weakness after minor exertion, neurological symptoms indicative of cerebral dysfunction and circulatory impairment, and a chronic relapsing course. Criteria diagnosis were reviewed by the International Consensus Criteria. Symptoms include a unique form of muscle fatigability with prolonged muscle weakness and muscle inflammation (myalgia), even after a minor degree of physical effort, circulatory impairment, memory and concentration trouble and sleep rhythm alterations. Symptoms vary and fluctuate over the day and are usually chronic. The cause is still unknown, but most investigators agree that the disorder is most likely the result of an abnormal immune system response to an infection or virus. There is no cure for ME. Treatment is aimed at relieving symptoms and preventing a worsening of symptoms. Each patient should have an individualized plan of treatment.

There is debate in the medical literature about the relationship between myalgic encephalomyelitis and chronic fatigue syndrome. There is no consensus on nomenclature or classification for these disorders. Different countries, organizations, and researchers continue to use different names to describe these conditions.