Grover's disease

What causes Grover's disease?

The cause of Grover's disease is not well understood. There are certain factors that are suspected to lead to the development of Grover's disease or worsen symptoms including:

  • Heat and sweating
  • Sunlight
  • Exposure to ionizing radiation (example sun, microwaves, X-rays)
  • End-stage renal disease (kidney failure)
  • Prolonged bed rest
  • Organ transplantation

Some cases of Grover's disease have been associated with certain medications, including antiviral medications, such as ribavirin and biologic agents used for cancer therapy, such as anastrozole. Grover's disease has additionally been found in individuals who have other similar dermatological diseases, such as atopic dermatitis and contact dermatitis.

Last updated on 05-01-20

How common is Grover's disease?

The prevalence (number of existing cases of a disease) and incidence (number of new cases over a period of time) have not been firmly established for Grover's disease. In a study from Switzerland, Grover's disease was diagnosed in 24 of more than 30,000 skin biopsies. This condition most commonly affects middle-aged white men, although other ages, ethnic groups, and genders may be affected.

Last updated on 05-01-20

How might Grover's disease be treated?

There is no cure for Grover's disease and treatment is usually based on a person's symptoms. Affected individuals are usually advised to avoid strenuous exercise and excessive sun exposure, as sweating and heat may induce more itchy spots. Initial treatment options include topical steroid creams such as hydrocortisone, anti-itch lotions containing menthol or camphor, and calcipotriol cream. For more severe cases, options include tetracycline, isotretinoin, antifungal pills such as itraconazole, PUVA phototherapy, and cortisone (steroid) injections. These treatments have important side effects and may not be necessary for mild cases.

Last updated on 05-01-20

Where To Start

American Osteopathic College of Dermatology

The American Osteopathic College of Dermatology provides information on Grover's disease.

Last updated on 04-27-20

Zabawski EJ. Transient Acantholytic Dermatosis Medscape Reference. March 31, 2016; Reference Link Riemann H, High WA. Grover's disease (transient and persistent acantholytic dermatosis) UpToDate. February 12, 2016; Reference Link

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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