Fibromuscular dysplasia

What causes fibromuscular dysplasia (FMD)?

The cause of FMD is unknown. It is likely that there are many factors that contribute to the development of this condition. These factors may include blood vessel abnormalities, tobacco use, hormone levels, and genetic predispositions.

Last updated on 05-01-20

Can fibromuscular dysplasia (FMD) be life-threatening?

In rare cases, FMD-related aneurysms can burst and bleed into the brain, causing stroke, permanent nerve damage, or death. Certain treatment can help reduce the risk of life- threatening complications of FMD. Patients with minimal narrowing of blood vessels may take a daily aspirin or a blood thinner (anticoagulant) to thin the blood and reduce the chances that a clot might form. Individuals with arterial disease who smoke should be encouraged to quit as smoking worsens the disease. Further treatment may include angioplasty, in which a small balloon is inserted through a catheter and inflated to open the artery. Small tubes called stents may be inserted to keep arteries open. Surgery may be needed to treat aneurysms that have the potential to rupture and cause bleeding within the brain.

Last updated on 05-01-20

What is the recurrence risk for stroke in fibromuscular dysplasia (FMD)?

Specific recurrence risks for stroke in FMD are not available. Case reports suggest that treatment with medicines and angioplasty can reduce the risk of recurrent stroke.

One research study followed 103 individuals with a history of carotid artery dissection, which can lead to stroke. They found that 5 out of these individuals had recurrence of carotid artery dissection and 80% of those with recurrence had FMD. They concluded that within this group, the rate of recurrence of carotid artery dissection was 1% per year and it was most often related to FMD.

Last updated on 05-01-20

Selected Full-Text Journal Articles

Genomics of Fibromuscular Dysplasia

Genomics of Fibromuscular Dysplasia. Di Monaco S, Georges A, Lengelé JP, Vikkula M, Persu A. Int J Mol Sci. 2018 May 21;19(5). Review.

Last updated on 04-27-20

Where To Start

The Fibromuscular Dysplasia Society of America (FMDSA)

The The Fibromuscular Dysplasia Society of America (FMDSA) provides information and support for Fibromuscular dysplasia

Last updated on 04-27-20

Name: The Fibromuscular Dysplasia Society of America (FMDSA) 20325 Center Ridge Road Suite 620
Rocky River, OH, 44116, United States
Phone: 216-834-2410 Toll Free: 888-709-7089 Email: Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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