Bone marrow necrosis

What causes bone marrow necrosis?

Bone marrow necrosis is associated with acute lymphoblastic leukemia (ALL), and is often discovered prior to initial diagnosis or around the time of recurrence of ALL.

Other associated cancers include lymphomas and solid tumors. Chronic myeloproliferative disorders have also been reported in association. Non-cancerous associated conditions, include infection, tuberculosis, drugs, sickle cell disease, disseminated intravascular coagulation, hemolytic-uremic syndrome, antiphospholipid syndrome, and hyperparathyroidism.

Cases of bone marrow necrosis have been reported in association with treatment with anticancer drugs, such as fludarabine, imatinib mesylate, and interferon alfa.

In some cases, the cause of bone marrow necrosis cannot be determined.

Last updated on 05-01-20

What is the typical prognosis (chance of recovery) of people with bone marrow necrosis?

Prognosis of people with bone marrow necrosis depends on the age of the patient and associated disease. Children with acute lymphoblastic leukemia (ALL) and bone marrow necrosis appear to have the same prognosis as children with ALL without the necrosis. Adults with bone marrow necrosis associated with a non-cancerous condition, may have a better chance of complete recovery and long term survival than adults with bone marrow necrosis associated with a blood cancer. It can be hard to distinguish bone marrow necrosis due to a drug or condition like disseminated intravascular coagulation versus an underlying cancer. This can make prognosis difficult to predict.

Last updated on 05-01-20

How might bone marrow necrosis be treated?

Bone marrow necrosis is often associated with thrombocytopenia, anemia, low blood count (pancytopenia), and other complications that should be managed with supportive measures until the underlying disease is effectively treated. Once the necrosis stops, the bone marrow cells are able to grow and thrive again.

Last updated on 05-01-20

Name: American Cancer Society 250 Williams Street NW
Atlanta, GA, 30329, United States
Toll Free: 1-800-227-2345 Url:
Name: AMC Cancer Research Center 3401 Quebec St, Suite 3200
Denver, CO, 80207, United States
Phone: 303-233-6501 Toll Free: 800-321-1557 Fax : 303-239-3400 Email: Url:
Name: Leukemia and Lymphoma Society 3 International Drive, Suite 200
Rye Brook, NY, 10573, United States
Phone: 1-(888) 557-7177 (general) Toll Free: 1-(800) 955-4572 (patients and families) Email: Url:

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