Autoimmune atrophic gastritis

What causes autoimmune atrophic gastritis?

Autoimmune atrophic gastritis is considered an autoimmune disorder. In people who are affected by this condition, the immune system mistakenly attacks the healthy cells of the stomach lining. Overtime, this can wear away the stomach's protective barrier and interfere with the absorption of several key vitamins (i.e. vitamin B12, iron, folate). This leads to the signs and symptoms of autoimmune atrophic gastritis.

Last updated on 05-01-20

How is autoimmune atrophic gastritis diagnosed?

A diagnosis of autoimmune atrophic gastritis is generally not suspected until characteristic signs and symptoms are present. Additional testing can then be ordered to confirm the diagnosis. This generally includes:

Last updated on 05-01-20

Is autoimmune atrophic gastritis inherited?

In some cases, more than one family member can be affected by autoimmune atrophic gastritis. Although the underlying genetic cause has not been identified, studies suggest that the condition may be inherited in an autosomal dominant manner in these families.

In autosomal dominant conditions, an affected person only needs a change (mutation) in one copy of the responsible gene in each cell. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene. These cases occur in people with no history of the disorder in their family. A person with the condition has a 50% chance with each pregnancy of passing along the altered gene to his or her child.

Last updated on 05-01-20

What is the long-term outlook for people with autoimmune atrophic gastritis?

The long-term outlook (prognosis) for people with autoimmune atrophic gastritis varies. The condition is associated with an increased risk of pernicious anemia, gastric polyps and gastric adenocarcinoma. Significant risk factors for the development of gastric cancer in autoimmune atrophic gastritis include pernicious anemia, severity of atrophy, intestinal metaplasia, length of disease duration, and age older than 50 years. Fortunately, early diagnosis and proper treatment can reduce the mortality of the condition.

Last updated on 05-01-20

How might autoimmune atrophic gastritis be treated?

The treatment of autoimmune atrophic gastritis is generally focused on preventing or treating vitamin B( and iron deficiencies. If pernicious anemia is already present at the time of diagnosis, vitamin B12 shots (injections) may be recommended. Since dietary and oral iron supplements do not usually improve iron levels, alternative iron therapy approaches may include receiving periodic intravenous (IV) iron (iron infusion) to increase iron stores or a daily dose of oral ferrous glycine sulfate to meet daily iron requirements. People with autoimmune atrophic gastritis should have their levels of B12 and iron monitored for the rest of their life.

In some cases, periodic endoscopy may also be recommended due to the increased risk of certain types of cancer.

Last updated on 05-01-20

Name: American Autoimmune Related Diseases Association (AARDA) 22100 Gratiot Avenue
Eastpointe, MI, 48021, United States
Phone: 586-776-3900 Toll Free: 800-598-4668 Fax : 586-776-3903 Email: Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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