Unicentric Castleman disease

What causes unicentric Castleman disease?

The exact underlying cause of unicentric Castleman disease (UCD) is poorly understood. However, some scientists suspect that an increased production of interleukin-6 (IL-6) by the immune system may contribute to the development of UCD. IL-6 is a substance normally produced by cells within the lymph nodes that helps coordinate the immune response to infection. Increased production of IL-6 may result in an overgrowth of lymphatic cells, leading to many of the signs and symptoms of UCD.

Last updated on 05-01-20

How is unicentric Castleman disease diagnosed?

Some people affected by unicentric Castleman disease (UCD) do not have any specific signs or symptoms. In these cases, the enlarged lymph node may be discovered incidentally (by chance) during a routine physical examination or when an imaging study is ordered to investigate a different medical condition. If UCD is suspected, the following tests may be recommended to help establish the diagnosis and rule out other conditions that cause similar features:

  • Blood tests can be ordered to evaluate the levels of Interleukin-6 (IL-6) and other substances in the body, which can be elevated in people with UCD. They can also be helpful in ruling out other autoimmune conditions and infections that are associated with similar signs and symptoms
  • Imaging studies (such as a CT scan, PET scan, MRI scan, and/or ultrasound) can help identify enlarged lymph node(s) and other health problems
  • Lymph node biopsy is usually recommended to confirm the diagnosis

Last updated on 05-01-20

Is unicentric Castleman disease inherited?

Although the exact underlying cause of unicentric Castleman disease (UCD) is unknown, it is thought to occur sporadically in people with no family history of the condition.

Last updated on 05-01-20

What is the long-term outlook for unicentric Castleman disease?

The long-term outlook (prognosis) for people with unicentric Castleman disease (UCD) is generally excellent. In many cases, the condition can be cured by surgically removing the affected lymph node. In fact, one study found that disease-free survival in people with UCD following surgery was approximately 93%.

Last updated on 05-01-20

How is unicentric Castleman disease treated?

Unicentric Castleman disease (UCD) can usually be cured by surgically removing the enlarged lymph node. If surgery isn't an option or the lymph node can not be removed completely, radiation therapy may be recommended to shrink and/or destroy the affected tissue.

Last updated on 05-01-20

Where To Start

Castleman Disease Collaborative Network

The Castleman Disease Collaborative Network, a global initiative dedicated to accelerating research and treatment for Castleman disease, provides information about Unicentric Castleman disease.

Last updated on 04-27-20

Castleman's disease resources

MayoClinic.com provides an information page for this topic. Click on the link to view this information.

Last updated on 04-27-20

Name: American Autoimmune Related Diseases Association (AARDA) 22100 Gratiot Avenue
Eastpointe, MI, 48021, United States
Phone: 586-776-3900 Toll Free: 800-598-4668 Fax : 586-776-3903 Email: aarda@aarda.org Url: https://www.aarda.org/
Name: Castleman Disease Collaborative Network P.O. Box 3614
Paso Robles, CA, 93447,
Phone: +1-610-304-0696 (for patients and families) Email: info@castlemannetwork.org Url: https://cdcn.org/ Office phone: +1-215-614-0935

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