Autoimmune gastrointestinaldysmotility (AGID) is a type of dysautonomia that may be idiopathic (cause unknown) or associated with cancer elsewhere in the body, most commonly small cell lung cancer. Signs and symptoms may include early satiety (feeling full quickly), nausea, vomiting, bloating, diarrhea, constipation and involuntary weight loss. Management options for AGID include treating specific symptoms, treatment of any underlying cancer if necessary, and/or immunotherapy. Nutrition and hydration therapy are important supportive treatment measures.
Source: GARD Last updated on 05-01-20
Treatment options for AGID are limited and generally aim to the relieve specific symptoms in each person. Therapies that may be useful include anti-emetics (drugs that relieve nausea and vomiting), prokinetic agents (e.g., erythromycin) to enhance motility, and cholinesterase inhibitors. Improvement of symptoms has also been reported with immunotherapy (intravenous immune globulin) and plasma exchange. Other types of treatments may be useful depending on symptoms and severity. Maintenance of nutrition and hydration, treatment of small-bowel bacterial overgrowth, and management of abdominal pain are important supportive measures.
Last updated on 05-01-20
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