Sickle cell anemia

How is sickle cell anemia inherited?

Sickle cell anemia is inherited in an autosomal recessive pattern, which means that both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. In regards to sickle cell anemia, a person who carries one copy of the mutated gene is said to be a carrier for the condition, or to have sickle cell trait. When two people who are carriers of an autosomal recessive condition have a child, there is a 25% (1 in 4) chance that the child will have the condition, a 50% (1 in 2) chance that the child will be a carrier like each of the parents, and a 25% (1 in 4) chance that the child will not have the condition and not be a carrier.

Last updated on 05-01-20

Clinical Research Resources

Sickle Transplant Alliance for Research

The Sickle Transplant Alliance for Research (STAR) is a non-profit organization created by a group of pediatric hematology and stem cell transplant doctors to conduct research to create better transplant approaches for individuals with sickle cell disease. STAR provides critical funding and an organized collaborative network where clinical trials can be conducted at many different institutions.

Last updated on 04-27-20

Newborn Screening

Sickle cell anemia

The Newborn Screening Coding and Terminology Guide has information on the standard codes used for newborn screening tests. Using these standards helps compare data across different laboratories. This resource was created by the National Library of Medicine.

Last updated on 04-27-20

Selected Full-Text Journal Articles

Sickle cell disease: old discoveries, new concepts, and future promise

Frenette PS, Atweh GF. Sickle cell disease: old discoveries, new concepts, and future promise. Journal of Clinical Investigation. 2007 Apr;117(4):850-8.

Last updated on 04-27-20

Name: American Sickle Cell Anemia Association DD Building at the Cleveland Clinic, Suite DD1-201
10900 Carnegie Avenue
Cleveland, OH, 44106, United States
Phone: 216-229-8600 Fax : 216-229-4500 Url:
Name: Sickle Cell Disease Association of America 3700 Koppers Street Suite 570
Baltimore, MD, 21227, United States
Phone: 410-528-1555 Toll Free: 800-421-8453 Fax : 410-528-1495 Email: Url:
Name: The Sickle Cell Information Center PO Box 109 Grady Memorial Hospital
80 Jesse Hill Jr Drive SE
Atlanta, GA, 30303, United States
Phone: 404-616-3572 Fax : 404-616-5998 Email: Url:
Name: European Network for Rare and Congenital Anaemias (ENERCA) University of Barcelona Red Cell Pathology Unit
C/Villarroel, 170 - 08036 Barcelona
Phone: (34) 93 451 5950 Fax : (34) 93 227 1764 Email: Url:
Name: March of Dimes 1275 Mamaroneck Avenue
White Plains, NY, 10605, United States
Phone: 914-997-4488 Toll Free: 888-663-4637 Fax : 914-997-4763 Email: Url:
Name: Sickle Cell Consortium 525 Tribble Gap Road, Box 1195
Cumming, GA, 30040,
Phone: 706-619-6029 Fax : 706-619-6029 Email: Url:
Vichinsky EP. Variant sickle cell syndromes UpToDate. March 28, 2014; Reference Link

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