Arthrogryposis multiplex congenita neurogenic type

What causes arthrogryposis multiplex congenita neurogenic type?

In arthrogryposis multiplex congenita neurogenic type (AMCN), arthrogryposis occurs as a result of the abnormal development of cells in the spinal cord (anterior horn cells) or brainstem (motor nuclei). AMCN often occurs sporadically (in a person with no family history of the condition), however families with multiple affected members have also been reported. In these families, genetic linkage studies may give information on how the condition is being passed through the family. The cause of AMCN is poorly understood. To date no single gene mutation has been found to cause AMCN.

Last updated on 05-01-20

What is the prognosis for people with arthrogryposis multiplex congenita neurogenic type?

Long term outlook is good for most people with AMCN, however symptoms can vary greatly. Life threatening respiratory problems in early infancy (first year of life) has been rarely reported. Some infants with AMCN have significant feeding problems, particularly those with brain malformation or small jaw (micrognathia). Children with AMCN affecting lower limbs are often able to walk, but may require knee ankle foot orthoses or corrective footwear. AMCN does not tend to worsen over time. Muscle strength does not tend to worsen, however contractures can lead to worsening of function ability. In the absence of brain malformations, outlook for cognition and learning is good.

Last updated on 05-01-20

How might arthrogryposis multiplex congenita neurogenic type be treated?

Treatment of arthrogryposis (joint contracture) involves occupational and physical therapy, well-fitted orthoses (splints and braces), and corrective surgery (if indicated). With treatment most kids can improve their range of motion, muscle strength, and function.

Last updated on 05-01-20

Name: Arthrogryposis Multiplex Congenita Support Inc. P.O. Box 6291
Spartanburg, SC, 29304, United States
Phone: +1-805-552-6274 Toll Free: 1-805-55-AMCSI (1-805-552-6274) Email: Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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