Pseudomyxoma peritonei

What causes pseudomyxoma peritonei?

The exact cause of pseudomyxoma peritonei (PMP) is currently unknown. No specific genetic or environmental factors have been found to cause PMP. Various types of tumors can lead to PMP, and it is not known why some cause PMP and others do not. Appendix tumors are the most common primary tumors associated with PMP, but tumors of the ovary, colon, stomach, pancreas, and urachus have also been reported in people with PMP.

It is generally thought that cells from a mucinous tumor (usually of the appendix) spread into the abdominal cavity, attaching themselves to the peritoneum and other organs in the abdomen. The tumor cells then continue to grow and produce mucin, which builds up and contributes to the signs and symptoms in people with PMP.

Last updated on 05-01-20

Is pseudomyxoma peritonei inherited?

There are no genetic factors known to be associated with pseudomyxoma peritonei (PMP), and to our knowledge, no familial cases of PMP have been reported. Therefore, family members of people with PMP are not thought to be at an increased risk for developing the condition.

Last updated on 05-01-20

How might pseudomyxoma peritonei be treated?

The treatment of pseudomyxoma peritonei depends on the underlying cause of the condition (the location and type of the original tumor, including whether it is malignant) and the extent of spreading. The approach depends on the size of the lesions and damage. It is needed to have an exploratory surgery (laparotomy) to find out which organs are affected. A combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is often the most successful treatment, and can achieve overall survival outcomes of up to 84% at 5 years. Cytoreductive surgery involves removing all lesions that can be removed. This is followed by hyperthermic intraperitoneal chemotherapy which involves placing heated chemotherapy drugs directly into the peritoneal cavity during surgery to destroy any remaining tumor cells that are too small to be seen.

Pressurized intraperitoneal aerosol chemotherapy is another option that can be combined with the surgery and have less complications of the hyperthermic form, but this treatment is still experimental and can be carried out only in specialized centers.The procedure is performed for 90 min under general anesthesia. The chemotherapy is vaporized in the form of an aerosol. Chemotherapy after the surgery may also improve the prognosis. Radiotherapy is not efficient because the tumor is not differentiated.

A good washing of the peritoneal cavity is useful, but the lesions frequently come back. The surgery must remove the appendix, and sometimes even a the right part of the colon, the uterus and the ovaries.

Last updated on 05-01-20

Where To Start

Appendix Cancer/Pseudomyxoma Peritonei Research Foundation

The Appendix Cancer/Pseudomyxoma Peritonei Research Foundation has a list of frequently asked questions for those diagnosed with Pseudomyxoma Peritonei (PMP), Appendix Cancer and related Peritoneal Surface Malignancies (PSM), and their caregivers. Click on the link above to view their answers to these questions.

Last updated on 04-27-20

Pseudomyxoma Survivor

Pseudomyxoma Survivor is a support network for those affected by PMP, appendix cancer and peritoneal surface malignancies. Click on the link above to view information about Pseudomyxoma peritonei.

Last updated on 04-27-20

Name: PMP Pals Network 225 Crossroads Boulevard Suite 390
Carmel, CA, 939123, United States
Phone: 408-909-7257 Email: Url:
Name: Appendix Cancer/Pseudomyxoma Peritonei Research Foundation ACPMP Research Foundation 2021 L Street NW Suite 101-244
Washington, DC, 20036-4909, United States
Phone: 833-227-6773 Email: Url:
Name: PMP Awareness Organization Url:
Name: Pseudomyxoma Survivor 9 Ilmington Close Hatton Park
Warwick CV35 7TL
United Kingdom
Phone: +44 300 30 200 50 Toll Free: +1 844 696 4478 Fax : +44 3030 401040 Email: Url:

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