Prolactinoma

Is a prolactinoma a genetic condition?

Most prolactinomas are thought to develop by chance without any known association to a genetic condition. However, up to 2.6% of individuals with a prolactinoma and no other symptoms may have a mutation in the MEN1 gene, which causes a genetic condition known as multiple endocrine neoplasia type 1 (MEN1). The chance of a prolactinoma being associated with MEN1 increases if the tumor is large or affects surrounding tissues (is invasive), or if the individual develops multiple tumors, especially in other glands such as the parathyroids or pancreas. Prolactinomas have also been associated with another, very rare genetic condition called AIP-Related Familial Isolated Pituitary Adenomas, caused by mutations in the AIP gene; only 50 families with this condition have been described in the medical literature.

Last updated on 05-01-20

Where To Start

The Pituitary Society

The Pituitary Society has a patient education booklet on Prolactinoma with information on symptoms, diagnosis, treatment, and more.

Last updated on 04-27-20

Name: The Pituitary Foundation 86 Colston Street Bristol BS1 5BB
United Kingdom
Phone: 0117 370 1320 Email: helpline@pituitary.org.uk Url: https://www.pituitary.org.uk/
Name: Pituitary Network Association P.O. Box 1958
Thousand Oaks, CA, 91358 , United States
Phone: +1-805-499-9973 Fax : +1-805-480-0633 Email: info@pituitary.org Url: https://pituitary.org/

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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