Don’t fight Prolactinoma alone.Find your community on the free RareGuru App.
Prolactinoma is a tumor of the pituitary gland that causes increased levels of the hormone prolactin. This hormone normally stimulates breast development and milk production in women. Prolactinoma can affect men or women. In women, the symptoms may include unusual milk production (galactorrhea) when not pregnant or nursing and having no menstrual cycles (amenorrhea). In men, the most common symptoms are decreased sex drive and infertility. Most prolactinomas occur by chance (sporadically) in people with no family history. In a small number of cases, prolactinoma may be caused by a genetic condition such as multiple endocrine neoplasia type 1 (MEN1) or familial isolated pituitary adenoma. Treatment for prolactinoma usually involves taking oral medications known as dopamine agonists. These medications can reduce prolactin levels and shrink the tumor. In more severe cases, radiation therapy or surgery may be needed.
Source: GARD Last updated on 05-01-20
Most prolactinomas are thought to develop by chance without any known association to a genetic condition. However, up to 2.6% of individuals with a prolactinoma and no other symptoms may have a mutation in the MEN1 gene, which causes a genetic condition known as multiple endocrine neoplasia type 1 (MEN1). The chance of a prolactinoma being associated with MEN1 increases if the tumor is large or affects surrounding tissues (is invasive), or if the individual develops multiple tumors, especially in other glands such as the parathyroids or pancreas. Prolactinomas have also been associated with another, very rare genetic condition called AIP-Related Familial Isolated Pituitary Adenomas, caused by mutations in the AIP gene; only 50 families with this condition have been described in the medical literature.
Last updated on 05-01-20
The Pituitary Society has a patient education booklet on Prolactinoma with information on symptoms, diagnosis, treatment, and more.
Last updated on 04-27-20
Do you have information about a disease, disorder, or syndrome? Want to suggest a symptom?
Please send suggestions to RareGuru!