Progressive multifocal leukoencephalopathy

What is the prognosis for individuals diagnosed with progressive multifocal leukoencephalopathy (PML)?

The mortality rates for those with HIV-PML have fallen dramatically from approximately 90 percent to around 50 percent according to most reports. For non-AIDS individuals with PML, the prognosis remains grim; the disease usually lasts for months and 80 percent die within the first 6 months, although spontaneous improvement has been reported. Those who survive PML can be left with severe neurological disabilities.

Last updated on 05-01-20

How might progressive multifocal leukoencephalopathy (PML) be treated?

Currently, the best available therapy is reversal of the immune-deficient state. This can sometimes be accomplished by alteration of chemotherapy or immunosuppression. In the case of HIV-associated PML, immediately beginning anti-retroviral therapy will benefit most individuals.

Last updated on 05-01-20

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