Partial androgen insensitivity syndrome

Are all males with partial androgen insensitivity syndrome infertile?

Men with partial androgen insensitivity syndrome (PAIS) are typically infertile, despite undergoing androgen therapy. However, although rare, there have been reported cases of fertile men with mild forms of PAIS and slightly impaired androgen receptor (AR) activity. In these cases, the external genitalia have usually been normal or very mildly affected.

There has also been a recently reported case of a man with PAIS having high- dose, prolonged testosterone therapy which resulted in significant improvement in sperm count and characteristics. In combination with an assisted reproductive technique called intracytoplasmic sperm injection (ICSI), this treatment resulted in fertility in the affected individual.

Last updated on 05-01-20

Name: AIS-DSD Support Group P.O. Box 2148
Duncan, OK, 75354-2148, United States
Email: http://aisdsd.org/contact Url: http://www.aisdsd.org/
Name: Accord Alliance 531 Route 22 East #244
Whitehouse Station, NJ, 08889 , United States
Phone: 908-349-0534 Fax : 801-349-0534 Email: http://www.accordalliance.org/contact/email-us.html Url: http://www.accordalliance.org/
Name: Androgen Insensitivity Syndrome Support Group UK Url: http://www.aissg.org/

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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