Paroxysmal nocturnal hemoglobinuria

Why does it appear that hemolysis mostly occurs at night?

The term "nocturnal" refers to the belief that hemolysis is triggered by acidosis during sleep. However, this observation was later disproved. In individuals with paroxysmal nocturnal hemoglobinuria, hemolysis has been shown to occur throughout the day, but the urine concentrated overnight produces the dramatic change in color. It is most noticeable in the morning, upon passing urine that has accumulated in the bladder during the night.

Last updated on 05-01-20

Name: Aplastic Anemia and MDS International Foundation 4330 East-West Highway, Suite 230
Bethesda, MD, 20814 , United States
Phone: +1-301-279-7202 Toll Free: 1-800-747-2820 Option 2 (Helpline) Fax : +1-301-279-7205 Email: Url:
Name: European Network for Rare and Congenital Anaemias (ENERCA) University of Barcelona Red Cell Pathology Unit
C/Villarroel, 170 - 08036 Barcelona
Phone: (34) 93 451 5950 Fax : (34) 93 227 1764 Email: Url:
Name: American Autoimmune Related Diseases Association (AARDA) 22100 Gratiot Avenue
Eastpointe, MI, 48021, United States
Phone: 586-776-3900 Toll Free: 800-598-4668 Fax : 586-776-3903 Email: Url:

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Drug Name Generic Name
Soliris eculizumab
Ultomiris Ravulizumab-cwvz

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