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Antiphospholipid syndrome (APS) is an autoimmune disorder. Signs and symptoms vary, but may include blood clots, miscarriage, rash, chronic headaches, dementia, and seizures. APS occurs when your body's immune system makes antibodies that attack phospholipids. Phospholipids are a type of fat found in all living cells, including blood cells and the lining of blood vessels. Most cases of APS occur in people with no family history of the disorder, however there are rare cases of APS clustering in a family. A widely accepted explanation for APS is that it is caused by a combination of gene mutations (making one more susceptible to APS) and an environmental exposure (such as to a virus). Currently there is not a cure for APS. The goal of treatment is to prevent blood clots from forming and to keep existing clots from getting larger.
Source: GARD Last updated on 05-01-20
An unknown % of people have these symptoms.
Click on a symptom to see definitions for associated terms.
|Bilateral renal agenesis|
|Increased urinary cortisol level|
|Cerebral cortical atrophy|
|Proximal lower limb amyotrophy|
|Bone marrow hypercellularity|
|Distal upper limb muscle weakness|
|Aplasia/Hypoplasia of the colon|
|Abnormal forearm bone morphology|
|Hemihypotrophy of lower limb|
|Opacification of the corneal stroma|
|Reduced sperm motility|
|Distal widening of metacarpals|
|Central retinal artery occlusion|
|Increased level of galactitol in plasma|
|Abnormality of the aryepiglottic fold|
|Autosomal dominant inheritance|
Antiphospholipid syndrome (APS) is an autoimmune disorder. It occurs when your body's immune system makes antibodies that attack phospholipids (a type of fat found in living cells). The exact reason for this is not known. While APS is not passed through families in a predictable pattern, genetics are thought to play a role. A widely accepted explanation for APS is that it is caused by a combination of gene mutations (making one more susceptible to APS) and an environmental exposure (such as a viral infection).
Research has found a few gene changes that occur in people with APS, however the contribution of these genetic changes to the development of the condition is unclear. Little is known about specific environmental triggers. Known risk factors include female sex and having other autoimmune-type disorders (such as Lupus).
Some people have APS antibodies, but have no signs or symptoms. These people are also at an increased risk for APS. In these cases, APS symptoms (for example blood clots) can be triggered by smoking, prolonged bed rest, pregnancy and the postpartum period, birth control pills, hormone therapy, cancer, and kidney disease.
Last updated on 05-01-20
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