Antiphospholipid syndrome

What causes antiphospholipid syndrome?

Antiphospholipid syndrome (APS) is an autoimmune disorder. It occurs when your body's immune system makes antibodies that attack phospholipids (a type of fat found in living cells). The exact reason for this is not known. While APS is not passed through families in a predictable pattern, genetics are thought to play a role. A widely accepted explanation for APS is that it is caused by a combination of gene mutations (making one more susceptible to APS) and an environmental exposure (such as a viral infection).

Research has found a few gene changes that occur in people with APS, however the contribution of these genetic changes to the development of the condition is unclear. Little is known about specific environmental triggers. Known risk factors include female sex and having other autoimmune-type disorders (such as Lupus).

Some people have APS antibodies, but have no signs or symptoms. These people are also at an increased risk for APS. In these cases, APS symptoms (for example blood clots) can be triggered by smoking, prolonged bed rest, pregnancy and the postpartum period, birth control pills, hormone therapy, cancer, and kidney disease.

Last updated on 05-01-20

Name: National Blood Clot Alliance 8321 Old Courthouse Road Suite 255
Vienna, VA, 22182, United States
Phone: +1-703-935-8845 Toll Free: 1-877-466-2568 (877-4NO-CLOT) Email: Url:
Name: Lupus Foundation of America 2121 K Street, N.W. Suite 200
Washington, DC, 20037 , United States
Phone: +1-202-349-1155 Toll Free: 1-800-558-0121 Fax : +1-202-349-1156 Email: Url:
Name: APS Foundation of America, Inc. P. O. Box 801
LaCrosse, WI, 54602-0801, United States
Email: Url:
Name: APS Support UK The Orchard White Hart Lande
Basingstoke Hampshire RG21 4AF
United Kingdom
Phone: 0300 323 9943 Email: Url:
Name: Vascular Cures 274 Redwood Shores Parkway, #717
Redwood City, CA, 94065, United States
Phone: +1-650-368-6022 Email: Url:
Name: American Autoimmune Related Diseases Association (AARDA) 22100 Gratiot Avenue
Eastpointe, MI, 48021, United States
Phone: 586-776-3900 Toll Free: 800-598-4668 Fax : 586-776-3903 Email: Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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