Ovarian carcinosarcoma

Is ovarian carcinosarcoma inherited?

Ovarian carcinosarcoma is not thought to be due to an inherited gene mutation. We are aware of one report of a woman with a BRCA2 gene mutation who developed ovarian carcinosarcoma. However, to our knowledge, this cancer typically occurs in women with no family history of ovarian carcinoma or a hereditary cancer syndrome.

Last updated on 05-01-20

What is ovarian carcinosarcoma?

Ovarian carcinosarcoma , also known as a malignant mixed mullerian tumor (MMMT) of the ovary, is a rare, aggressive cancer of the ovary with characteristics of two types of cancer: carcinoma and sarcoma. Because women with this cancer often have no symptoms, more than half of women are diagnosed at an advanced stage. When present, symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating, or other digestive problems. The cause of ovarian carcinosarcoma is not yet understood. Treatment usually consists of surgery to remove the tumor and chemotherapy. The chance of recovery and long-term survival (prognosis) is poor, with a reported 5-year survival rate of about 28%.

Last updated on 05-01-20

How might ovarian carcinosarcoma be treated?

Because ovarian carcinosarcoma is rare, there are no established treatment guidelines. Treatment decisions are based on the unique features of each individual's diagnosis. The National Comprehensive Cancer Network (NCCN), a group of physicians and researchers who strive to improve cancer care, recommends that women with ovarian carcinosarcoma be treated similarly to women with ovarian carcinoma (also called epithelial ovarian cancer), which is the most common type of ovarian cancer.

Currently, treatment for ovarian carcinosarcoma usually begins with surgery to remove as much of the cancer as possible. Chemotherapy may be used to destroy any cancer cells that could be in the body after surgery. Medications that contain platinum (such as cisplatin or carboplatin) seem to be the most effective chemotherapies for ovarian carcinosarcoma. Recent evidence suggests that another medication called ifosfamide may increase the effectiveness of treatment when used in combination with platinum-based medications.

Last updated on 05-01-20

Name: Ovarian Cancer Research Alliance 14 Pennsylvania Plaza, Suite 2110
New York, NY, 10122, United States
Phone: 212-268-1002 Toll Free: 866-399-6262 Fax : 202-331-2292 Email: info@ocrahope.org Url: https://ocrahope.org
Name: National Ovarian Cancer Coalition 2501 Oak Lawn Avenue, Suite 435
Dallas, TX, 75219 , United States
Phone: 214-273-4200 Toll Free: 888-OVARIAN Fax : 214-273-4201 Email: nocc@ovarian.org Url: http://www.ovarian.org/
Name: The Liddy Shriver Sarcoma Initiative 17 Bethea Drive
Ossining, NY, 10562-1620 , United States
Phone: 914-762-3251 Url: http://sarcomahelp.org/
Name: Minnesota Ovarian Cancer Alliance 4604 Chicago Ave
Minneapolis, MN, 55407,
Phone: 612-822-0500 Email: INFO@MNOVARIAN.ORG Url: http://mnovarian.org/
Name: The Gynecological Carcinosarcoma Project GCS Project 2795 Estates Drive
Park City, UT, 84060,
Email: info@gcsproject.org Url: http://gcsproject.org/
Ana Rath and Stéphanie NGUENGANG WAKAP. Prevalence of rare diseases: Bibliographic data », Orphanet Report Series, Rare Diseases collection, January 2020, Number 2 : Diseases listed by decreasing prevalence, incidence or number of published cases Orphanet Report Series - Prevalence of rare diseases: Bibliographic data - January 2020 - Number 2. January 2020; Number 2. 64. Reference Link

Connect with other users with Ovarian carcinosarcoma on the RareGuru app

Do you have information about a disease, disorder, or syndrome? Want to suggest a symptom?
Please send suggestions to RareGuru!

The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

People Using the App

Join the RareGuru Community

To connect, share, empower and heal today.

People Using the App