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Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. They originate from cells that were meant to form sex cells (i.e., sperm or eggs). They are often large and have a tendency to spread more quickly than the other type of germ cell tumor (i.e., seminoma type). Possible early signs of this cancer include chest pain and breathing problems.
Source: GARD Last updated on 05-01-20
The cause of cancer in general can be broadly described as multifactorial, with genetic, environmental, medical, and lifestyle factors interacting to produce a given cancer. Knowledge of the role of genetics in certain cancers has greatly improved over time, but much remains to be learned. We were unable to find information in the medical literature that suggests that having a first degree relative, such as a parent, with nonseminomatous germ cell tumor is a risk factor for this cancer. At this time, recognized risk factors for nonseminomatous germ cell tumor include being 20-years-old or older, being male, and having Klinefelter syndrome. Click here to learn more about Klinefelter syndrome. Click here to read more about cancer genetics in general, including a list of the general signs of hereditary cancer.
Last updated on 05-01-20
While we are not aware of a clinical trial currently investigating the role of genetics in nonseminomatous germ cell tumor, you may be interested in learning more about the Cancer Genetics Network. The Cancer Genetics Network is a national network of centers specializing in the study of inherited predisposition to cancer.
You may also find it helpful to periodically search for new trials at ClinicalTrials.gov. The National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. To search for a study, use "genetic AND germ cell tumor" as your search term.
You can also contact the Patient Recruitment and Public Liaison (PRPL) Office at the National Institutes of Health (NIH). We recommend calling the toll-free number listed below to speak with a specialist, who can help you determine if you are eligible for any clinical trials.
Patient Recruitment and Public Liaison Office (PRPL)
NIH Clinical Center
Bethesda, Maryland 20892-2655
Web site: http://clinicalcenter.nih.gov/
ClinicalTrials.gov provides ahelpful guide for information about participating in a clinical trial. Resources for travel and lodging assistance are listed on the National Center for Advancing Translational Sciences Office of Rare Diseases Research (NCATS-ORDR) website, part of the National Institutes of Health (NIH).
Lastly, you may be interested in learning more about the Cancer Genome Anatomy Project (CGAP). The Project seeks to determine the gene expression profiles of normal, precancer, and cancer cells, leading eventually to improved detection, diagnosis, and treatment for the patient.
Last updated on 05-01-20
The Testicular Cancer Resource Center has an information page on extragonadal germ cell cancer. Click on the link above to view the information page.
Last updated on 04-27-20
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