Niemann-Pick disease type B

Is Niemann-Pick disease type B and cellulite related?

Currently, we are not aware of an association between Niemann-Pick disease type B and cellulite. People with Niemann-Pick disease have an abnormal lipid (fat) metabolism which causes lipids to build-up in the spleen, lung, liver, bone marrow, and brain. Signs and symptoms may include enlarged liver and spleen (hepatosplenomegaly), reduced growth, frequent lung infections, and reduced numbers of blood cells involved in clotting (platelets).

Cellulite is often found in the pelvis, thighs, and abdomen. It is estimated to affect 85% to 95% of women. According to a review article on cellulite by Khan MH et al., 2010, cellulite is thought to result from the "herniation of subcutaneous fat within fibrous connective tissue." The underlying cause for this herniation is not well understood, and is likely multifaceted.

You can read more about cellulite at the following link to MedlinePlus.gov.
http://www.nlm.nih.gov/medlineplus/ency/article/002033.htm

Last updated on 05-01-20

Selected Full-Text Journal Articles

Niemann-Pick disease type B

Wasserstein MP, Desnick RJ, Schuchman EH, Hossain S, Wallenstein S, Lamm C, McGovern MM. The natural history of type B Niemann-Pick disease: results from a 10-year longitudinal study. Pediatrics. 2004 Dec;114(6):e672-7.

Last updated on 04-27-20

Name: Metabolic Support UK 5 Hilliards Court Sandpiper Way
Chester Business Park
Chester, CH4 9QP, United Kingdom
Phone: 0845 241 2173 Toll Free: 0800 652 3181 Email: https://www.metabolicsupportuk.org/contact-us Url: https://www.metabolicsupportuk.org
Name: National Niemann-Pick Disease Foundation, Inc. P.O. Box 49 401 Madison Avenue, Suite B
Ft. Atkinson, WI, 53538, United States
Phone: 920-563-0930 Toll Free: 877-CURE-NPC (287-3672) Fax : 920-563-0931 Email: nnpdf@nnpdf.org Url: http://www.nnpdf.org

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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