Is neurofibromatosis inherited?

Neurofibromatosis is inherited in an autosomal dominant manner. This means that to be affected, a person only needs a change (mutation) in one copy of the responsible gene in each cell. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene. These cases occur in people with no history of the disorder in their family. A person with neurofibromatosis has a 50% chance with each pregnancy of passing along the altered gene to his or her child.

Last updated on 05-01-20

Name: Children's Tumor Foundation CTF 120 Wall Street, 16th floor
New York, NY, 10005-3904, United States
Phone: +1-212-344-6633 Toll Free: 1-800-323-7938 Fax : +1-212-747-0004 Email: Url:
Name: Neurofibromatosis Network 213 S. Wheaton Ave.
Wheaton, IL, 60187, United States
Phone: +1-630-510-1115 Toll Free: 1-800-942-6825 Fax : +1-630-510-8505 Email: Url:
Name: March of Dimes 1275 Mamaroneck Avenue
White Plains, NY, 10605, United States
Phone: 914-997-4488 Toll Free: 888-663-4637 Fax : 914-997-4763 Email: Url:
Evans DG. Neurofibromatosis type 2 UpToDate. August 3, 2016; Reference Link Korf BR. Neurofibromatosis type 1 (NF1): Pathogenesis, clinical features, and diagnosis UpToDate. June 19, 2015; Reference Link Friedman JM. Neurofibromatosis 1 GeneReviews. September 4, 2014; Reference Link

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