MURCS association

What causes MURCS association?

The cause of MURCS association is not known. Most affected individuals have no history of the condition in their family. Symptoms of the condition develop during pregnancy but have not been linked to any known teratogens.

Last updated on 05-01-20

What is MURCS association?

MURCS association stands for (MU)llerian, (R)enal, (C)ervicothoracic (S)omite abnormalities and is a developmental disorder that primarily affects the reproductive and urinary systems. Most individuals with MURCS association are female, although males can also have this condition. Females with MURCS association can have an absent or abnormally shaped uterus. In rare cases, the vagina is also affected. Both males and females with MURCS association can have absent or abnormally formed reproductive tubes (usually the fallopian tubes in females and the vas deferens in males), kidney abnormalities, and short stature (adult height of less than 5 feet). Additional symptoms might include fused spinal bones in the neck and upper back and hearing loss. These symptoms may vary from person to person. MURCS association is present at birth but may not be noticed until after puberty, especially when an affected female does not receive her first period. This condition does not alter a person’s life expectancy.

Last updated on 05-01-20

How might MURCS association be treated?

Some reproductive abnormalities may benefit from surgery. Individuals with MURCS association do not typically have hormone dysfunction, so hormone therapy may not be beneficial.

Last updated on 05-01-20

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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