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Androgen insensitivity syndrome is a condition that affects sexual development before birth and during puberty. People with this condition are genetically male, with one X chromosome and one Y chromosome in each cell. Because their bodies are unable to respond to certain male sex hormones (called androgens), they may have some physical traits of a woman. Androgen insensitivity syndrome is caused by mutations in the AR gene and is inherited in an X-linked recessive pattern.
Source: GARD Last updated on 05-01-20
There are different forms of androgen insensitivity.
Complete androgen insensitivity syndrome occurs when the body cannot respond at all to certain male sex hormones (called androgens). People with this form of the condition have female sex characteristics, but do not have a uterus. Without a uterus, they do not menstruate and are unable to carry a pregnancy or have their own biological child (infertile). They are typically raised as females and have a female gender identity.
The partial and mild forms of androgen insensitivity syndrome occur when the body is able to partially respond to androgens. People with partial androgen insensitivity (also called Reifenstein syndrome) can have normal female sex characteristics, both male and female sex characteristics, or normal male sex characteristics. They may be raised as males or as females, and may have a male or a female gender identity.
Last updated on 05-01-20
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