Microscopic polyangiitis

What causes microscopic polyangiitis (MPA)?

The cause of MPA is unknown. It is not contagious, does not usually run in families, and is not a form of cancer. The immune system is thought to play a critical role in the development of MPA. It is thought that the immune system becomes overactive and causes blood vessel and tissue inflammation, which leads to organ damage. It is not known what causes the immune system to become overactive.

Last updated on 05-01-20

What is microscopic polyangiitis (MPA)?

Microscopic polyangiitis (MPA) is a disorder that causes blood vessel inflammation (vasculitis), which can lead to organ damage. The kidneys, lungs, nerves, skin, and joints are the most commonly affected areas of the body. MPA is diagnosed in people of all ages, all ethnicities, and both genders. The cause of this disorder is unknown.

Last updated on 05-01-20

What is the long-term outlook for microscopic polyangiitis (MPA)?

The prognosis for MPA depends on the severity of the condition. Early diagnosis and prompt treatment lead to a better overall prognosis. With treatment, 75 percent of individuals achieve complete remission. After achieving remission, it is possible for MPA to recur (often referred to as a “relapse”). Relapses occur in about 30-50% of people with MPA. Achieving remission is again possible for most people with MPA.

Last updated on 05-01-20

Do children diagnosed with microscopic polyangiitis (MPA) receive different treatment or have a different prognosis than adults?

Limited information is available on pediatric vasculitis and how it differs from vasculitis in adults. Most decisions regarding the treatment of children with MPA are made by using data obtained from research on adults. The Childhood Arthritis Rheumatology Research Alliance conducted research on the feasibility of establishing a registry of children with chronic systemic vasculitis for participation in future research. The abstract for this article is available through PubMed. You may wish to contact this organization to learn more about pediatric vasculitis research.

Childhood Arthritis Rheumatology Research Alliance
Dept. of Pediatrics, Div. of Rheumatology
300 Pasteur Drive
Boswell Building A081
Stanford, CA 94305-5208
Phone: 650-736-4364
Fax: 650-736-4344
Online email: http://www.carragroup.org/contact_view.do
Web site: http://www.carragroup.org/

Last updated on 05-01-20

How might microscopic polyangiitis (MPA) be treated?

The treatment of MPA is dependent on the extent of the disease, rate of progression, and the degree of inflammation. The goal of treatment is to stop organ damage that occurs as a result of MPA and involves use of medications that suppress the immune system. Treatment is typically carried out in three phases:

  1. Remission induction using prednisone and cyclophosphamide. This phase usually lasts between 4 and 6 months.
  2. Remission maintenance using prednisone and replacing cyclophosphamide with other medications such as methotrexate and azathioprine. This phases usually lasts between 12 and 24 months.
  3. Treatment of relapse utilizing medications from phase one or other therapies such as intravenous immunoglobulin for resistant cases.

Last updated on 05-01-20

Where To Start

Microscopic polyangitis - Vasculitis Foundation

The Vasculitis Foundation has an information page on microscopic polyangiitis on their Web site. Click on the Vasculitis Foundation link to view this information.

Last updated on 04-27-20

Microscopic polyangiitis - The Johns Hopkins Vasculitis Center

The Johns Hopkins Vasculitis Center Web site has an information page on microscopic polyangiitis. Click on the Johns Hopkins link to view this information.

Last updated on 04-27-20

Name: Vasculitis Foundation P.O. Box 28660
Kansas City, MO, 64188, United States
Phone: +1-816-436-8211 Toll Free: 1-800-277-9474 Fax : +1-816-656-3838 Email: https://www.vasculitisfoundation.org/contact-us-2/ Url: https://www.vasculitisfoundation.org/
Name: American Autoimmune Related Diseases Association (AARDA) 22100 Gratiot Avenue
Eastpointe, MI, 48021, United States
Phone: 586-776-3900 Toll Free: 800-598-4668 Fax : 586-776-3903 Email: aarda@aarda.org Url: https://www.aarda.org/

Note, these links are external searches against the National Laboratory of Medicine's drug database. You may need to adjust the search if there are no results found.

Drug Name Generic Name
Rituxan rituximab

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