Microcystic adnexal carcinoma

What causes microcystic adnexal carcinoma?

The underlying cause of this condition is not fully known. Risk factors appear to include radiation treatment, ultraviolet exposure, immunosuppression, and possibly genetics.

Last updated on 05-01-20

Is microcystic adnexal carcinoma hereditary?

A case of microcystic adenxal carcinoma occurring in siblings suggests a genetic component. While a specific risk has not been formulated (there are too few cases to speculate), a positive family history may suggest an increased risk for an immediate family member developing a tumor.

Last updated on 05-01-20

Is radiation therapy a recommended treatment for microcystic adnexal carcinoma?

Unfortunately, because microcystic adnexal carcinoma is a rare cancer, there is currently not enough information to determine if radiation therapy is an effective treatment for this disease. There are no guidelines for the use of radiation therapy as treatment for microcystic adnexal carcinoma, and little is known about the dose of radiation that might be needed to be effective. Two articles studying a total of 17 patients receiving radiation therapy for microcystic adnexal carcinoma have suggested that there may be a benefit of radiation therapy for decreasing the chances of the tumor regrowing (recurrence), and the authors suggest that this treatment could be considered if there is evidence that cancer cells remain after surgery, or in situations where additional surgery cannot be done. However, another article raises concerns about the use of radiation therapy considering the small number of patients studied, the report of one patient's disease potentially worsening after radiation therapy, and the belief that exposure to radiation may be a risk factor for the initial development of this tumor.

Last updated on 05-01-20

Wetter R, Goldstein GD. Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge Dermatologic Therapy. Nov-Dec 2008; 21(6). 452-458. Reference Link

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