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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)* is a group of diseases (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis), * characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, stomach, intestine, and lung. Skin lesions, such as purpura and urticaria, result when blood from small vessels leaks under the skin. AAV occurs when neutrophils attack small and medium vessels of the body. The underlying reason for this remains unclear. Treatment includes cyclophosphamide, glucocorticoids and other autoimmune drugs such as rituximab.
Source: GARD Last updated on 05-01-20
Dr. Ronald Falk presented the annual NIH Astute Clinician Lecture in November 2016 at the NIH Clinical Center. Falk discussed Anti-Neutrophil Cytoplasmic Autoantibodies (ANCA) vasculitis in his lecture titled, "Perspective on Autoimmunity: A View from the ANCA Vasculitis Looking Glass." The lecture is for medical professionals, but may be of interest to anyone who is looking for detailed information on ANCA vasculitis.
Last updated on 04-27-20
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