Mesangial proliferative glomerulonephritis

What causes mesangial proliferative glomerulonephritis?

Most cases of mesangial proliferative glomerulonephritis (MPGN) are associated with IgA nephropathy (IgAN). In general, IgAN has been known to be the most common type of glomerulonephritis in most countries.

Mesangial cell proliferation, which characterizes MPGN, is a common feature of various kidney disorders. It may be seen in several diseases in addition to IgAN, including IgM nephropathy (IgMN), lupus nephritis (caused by lupus), Alport’s syndrome, and post infectious glomerulonephritis.

In some cases, the underlying cause of MPGN is unclear.

Last updated on 05-01-20

Is mesangial proliferative glomerulonephritis inherited?

MPGN may be associated with a variety of kidney disorders, some of which may run in families. While no specific gene or genes responsible for MPGN have been identified, genetic predisposition may be a risk factor. For example, most cases of MPGN are associated with IgA nephropathy (IgAN), which scientists think is an autoimmune disease. For some people, IgAN runs in families. However, IgAN may also be related to respiratory or intestinal infections, and the immune system’s response to these infections.

Last updated on 05-01-20

Name: National Kidney Foundation 30 East 33rd Street
New York, NY, 10016, United States
Phone: 212-889-2210 Toll Free: 800-622-9010 Fax : 212-689-9261 Email: Url:
Name: American Association of Kidney Patients 3505 E. Frontage Rd., Suite 315
Tampa, FL, 33607-1796, United States
Phone: 813-636-8100 Toll Free: 800-749-2257 Fax : 813-636-8122 Email: Url:
Name: American Kidney Fund, Inc. 6110 Executive Boulevard Suite 1010
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Name: NephCure Kidney International 150 S. Warner Road Suite 402
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Phone: 1-866-NephCure (637-4287) Email: Url:
Name: National Kidney Federation NKF The Point Shireoaks
Coach Road Worksop Notts S81 8BW
United Kingdom
Phone: 0845 601 02 09 Url:

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