Megalocytic interstitial nephritis

What causes malakoplakia?

The cause of malakoplakia is unknown, but is thought to be associated with immunodeficiency or autoimmune disorders, such as hypogammaglobinlinemia, therapies that suppress the immune system, cancer, a chronic debilitating disorder, rheumatoid arthritis, and AIDS.

Last updated on 05-01-20

What is malakoplakia?

Malakoplakia is a rare chronic inflammatory disease. It most commonly involves the urogenital system (reproductive organs and urinary system), but may also be found in other regions of the body, including the pelvis, bones, lungs, thyroid gland, gastrointestinal (digestive) tract, skin, and kidneys. Symptoms of malakoplakia differ depending on the involved area. For example, when the skin is affected the malakoplakia may appear rash-like with small areas of itchy, reddened skin that may be painful and/or fluid filled.

The cause of malakoplakia is not well understood. It is thought to be related to an issue with the function of one's macrophages, which are one type of cell within the immune system that respond to foreign invaders (bacteria). E.coli is the most common type of bacteria that leads to malakoplakia. Individuals with a compromised immune system have an elevated risk to develop malakoplakia. Treatment typically begins with antibiotics.

Last updated on 05-01-20

What is megalocytic interstitial nephritis?

Megalocytic interstitial nephritis is a rare chronic kidney disease that is characterized by inflammation of the kidney. The inflammation is mainly found in an area of the kidney called the renal cortex, which is in the outer portion of the kidney. The exact cause of megalocytic interstitial nephritis is not clear; however, it is associated with an impaired function of histiocytes (immune cell that eats foreign substances to protect the body from infection), particularly in patients that have a lowered immune system. Alcohol abuse may also be a risk factor. Generalized symptoms of kidney inflammation (interstitial nephritis) may include: blood in the urine, fever, increased or decreased urine output, mental status changes, rash, and swelling of the body. Treatment is dependent on the underlying cause (if identified) and the stage of the disease.

Last updated on 05-01-20

What are the signs and symptoms of malakoplakia of the kidney?

Symptoms of malakoplakia of the kidney are similar to symptoms present during a kidney infection including fever, back side (flank) or groin pain, abdominal pain, frequent urination, pus or blood in the urine, and a burning sensation with urination. Malakoplakia can lead to kidney failure. It may affect one or both kidneys and often appears as a mass or tumor which can be misdiagnosed as renal cancer.

Last updated on 05-01-20

Are malakoplakia of the kidney and megalocytic interstitial nephritis related?

There is no clear clinical distinction between megalocytic interstitial nephritis and malakoplakia. Some researchers suspect that megalocytic interstitial nephritis might be an early stage of malakoplakia or might represent a variation of malakoplakia. Some studies indicate that a kidney biopsy can be useful in differentiating malakoplakia, megalocytic interstitial nephritis, and xanthogranulomatous pyelonephritis. All three of these conditions are chronic inflammatory disorders with similar clinical signs and symptoms.

Last updated on 05-01-20

Where To Start

NIDDK - Chronic kidney disease

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), provides information on chronic kidney disease that you may find helpful. Click on the link above to view this information.

Last updated on 04-27-20

Name: National Kidney Foundation 30 East 33rd Street
New York, NY, 10016, United States
Phone: 212-889-2210 Toll Free: 800-622-9010 Fax : 212-689-9261 Email: Url:
Name: American Association of Kidney Patients 3505 E. Frontage Rd., Suite 315
Tampa, FL, 33607-1796, United States
Phone: 813-636-8100 Toll Free: 800-749-2257 Fax : 813-636-8122 Email: Url:
Name: The Kidney Foundation of Canada 700-15 Gervais Drive Toronto Ontario M3C 1Y8
Phone: 416-445-0373 Toll Free: 800-387-4474 Fax : 416-445-7440 Email: Url:
Name: American Kidney Fund, Inc. 6110 Executive Boulevard Suite 1010
Rockville, MD, 20852, United States
Phone: 301-881-3052 Toll Free: 866-300-2900 Email: Url:

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