Medullary sponge kidney

What is the cause of medullary sponge kidney?

The cause of medullary sponge kidney (MSK) is unknown. There have been reports that some people with MSK have a change in a gene known as _GDNF, _but this gene has not been seen in all cases of MSK.

Last updated on 05-01-20

How is medullary sponge kidney diagnosed?

Medullary sponge kidney (MSK) is diagnosed based on the symptoms and confirmed by laboratory testing and imaging. The test used most often to diagnose MSK is intravenous urography (IVU). Other types of imaging (CT scan, MRI, xray) may also be used.

Last updated on 05-01-20

How is medullary sponge kidney inherited?

Medullary sponge kidney (MSK) is not usually inherited in families. Most people with MSK are the only person in their family to have this condition.

In a few families, MSK seems to be inherited in an autosomal dominant pattern, although people with MSK in the same family can have very different symptoms.

Last updated on 05-01-20

What is the long-term outlook for people with medullary sponge kidney?

Medullary sponge kidney is typically diagnosed in early adulthood. Many people with medullary sponge kidney (MSK) have few symptoms and no long-term complications. Rarely, MSK will result in severe kidney disease requiring kidney transplant.

Last updated on 05-01-20

How many people have medullary sponge kidney?

The exact number of people with medullary sponge kidney is unknown. It is estimated that between 5/10,000 and 5/100,000 people may have this condition.

Last updated on 05-01-20

How is medullary sponge kidney treated?

Treatment for medullary sponge kidney (MSK) is based on preventing and treating the symptoms of the condition. Increased water intake and a special diet can help reduce the number of kidney stones. Kidney stones can also be removed by surgery, laser treatments, and other methods. Antibiotics can be used to treat urinary tract and kidney infections. Pain medications may be helpful for some.

Specialists involved in the care of people with MSK include:

  • A nephrologist (kidney specialist)
  • A dietitian (expert in food and nutrition)

Last updated on 05-01-20

Name: National Kidney Foundation 30 East 33rd Street
New York, NY, 10016, United States
Phone: 212-889-2210 Toll Free: 800-622-9010 Fax : 212-689-9261 Email: Url:
Name: American Association of Kidney Patients 3505 E. Frontage Rd., Suite 315
Tampa, FL, 33607-1796, United States
Phone: 813-636-8100 Toll Free: 800-749-2257 Fax : 813-636-8122 Email: Url:
Name: The Kidney Foundation of Canada 700-15 Gervais Drive Toronto Ontario M3C 1Y8
Phone: 416-445-0373 Toll Free: 800-387-4474 Fax : 416-445-7440 Email: Url:
Name: American Kidney Fund, Inc. 6110 Executive Boulevard Suite 1010
Rockville, MD, 20852, United States
Phone: 301-881-3052 Toll Free: 866-300-2900 Email: Url:
Iman TH, Patail H, Patail H. Medullary Sponge Kidney: Current Perspectives Int J Nephrol Renovasc Dis. Sep 26, 2019; 12. 213-218. Reference Link Gambaro G, Danza FM, Fabris A. Medullary sponge kidney Curr Opin Nephrol Hypertens. 2013; 22. 241-246. Reference Link Gambaro G, Goldfarb DS, Baccaro R, Hirsch J, Topilow N, D’Alonzo S, Gambassi G, Ferraro PM. Chronic pain in medullary sponge kidney: A rare and never described clinical presentation J Nephrol. Aug, 2018; 31(4). 537-542. Reference Link Goldfarb D. Medullary sponge kidney UpToDate. Aug 9, 2019; Reference Link

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