Marchiafava Bignami disease

The exact cause of Marchiafava Bignami disease is not known. Alcoholism seems to be the greatest risk factor for the disease, although rare cases have occurred in individuals who did not drink alcohol. Nutritional factors have been suspected, but no specific nutrient has been identified. Other possible causes include electrolyte disturbances or direct toxicity of ethanol or other substances.

You can find some additional general information and resources about this condition on our website by clicking here.

PubMed, a searchable database of biomedical journal articles, lists some articles and case reports that discuss Marchiafava Bignami disease in non- alcoholic individuals. You may view a list of some of these articles by clicking here. Although not all of the articles are available for free online, most articles listed in PubMed have a summary available. To obtain the full article, contact a medical/university library or your local library for interlibrary loan. You can also order articles online through the publisher’s Web site. Using "Marchiafava Bignami" as your search term should help you locate all articles specific to the disease. Use the Limits or Advanced Search features to narrow your search results. Click here to view a search. http://www.ncbi.nlm.nih.gov/PubMed

The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link http://nnlm.gov/members/. You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.

Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimes progress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism.

In individuals who have recovered from Marchiafava Bignami disease (MBD), it is not clear whether improvement was a result of vitamin supplementation or merely a reflection of the disease's natural history. Treatment should generally focus on nutritional support and rehabilitation from alcoholism (when alcoholism is present). Various treatments, including those typically used for alcoholism in general, have been given to patients with MBD. Some have improved and some have not. The most common treatments are thiamine and other B vitamins (especially vitamin B-12 and folate, which is not a B vitamin but is commonly given with B-12). No specific proven treatment is available. It has been recommended that individuals who survive the disease receive rehabilitation and, if appropriate, alcohol and nutritional counseling.