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Don’t fight Mantle cell lymphoma alone.
Find your community on the free RareGuru App.Mantle cell lymphoma (MCL) belongs to a group of diseases known as non- Hodgkin’s lymphomas (NHL). NHL's are cancers that affect the the lymphatic system (part of the immune system). In MCL, there are cancerous B-cells (a type of immune system cell). The cancerous B-cells are within a region of the lymph node known as the mantle zone. Although MCLs are slow-growing cancers, the cancer is usually widespread by the time it is diagnosed. In these situations, treatment must be intensive since MCL can become life threatening within a short period of time. MCL accounts for 6% of all NHL's and is mostly found in males during their early 60s.
Source: GARD Last updated on 05-01-20
Signs and symptoms of mantle cell lymphoma (MCL) may include swelling of the lymph nodes, fever, night sweats, weight loss, and fatigue. Some people have no to few signs of MCL leading to delayed diagnosis and treatment.
Of note, people with MCL may be at an increased risk for gastrointestinal issues, such as obstruction, intussusception, and multiple intestinal polyps, as well as a very high white blood cell count.
Last updated on 05-01-20
80%-99% of people have these symptoms.
Click on a symptom to see definitions for associated terms.
| Intrauterine growth retardation |
| B-cell lymphoma |
| Lymphadenopathy |
30%-79% of people have these symptoms.
Click on a symptom to see definitions for associated terms.
| Abnormality of bone marrow cell morphology |
| Fever |
| Bruxism |
| Slender finger |
| Fatigue |
| Recurrent opportunistic infections |
| Anorexia |
| Splenomegaly |
| Weight loss |
5%-29% of people have these symptoms.
Click on a symptom to see definitions for associated terms.
| Abnormality of the gastrointestinal tract |
Most lymphomas are not inherited, but rather are acquired when the DNA within select body cells has been damaged (somatic DNA damage). Some risk factors for non-Hodgkin lymphomas (NHL) include age (older), gender (male), race (white), and having a condition which weakens the immune system, such as autoimmune conditions, certain genetic disorders, being on immune suppressing medications, HIV/AIDS, HTLV-1, Ebstein-Barr virus, and helicobacter pylori infection.
Last updated on 05-01-20
The following tests and procedures may be used to diagnose mantle cell lymphoma:
Physical exam and medical history
Flow
cytometry
Bone marrow
aspiration
or biopsy
Lymph
node biopsy (surgical removal of all or part of a lymph node)
If cancer is found, the following tests may be done to study the cancer cells:
Immunohistochemistry
Cytogenetic
analysis
FISH
Immunophenotyping
Last updated on 05-01-20
Treatment of Mantle cell lymphoma (MCL) most often involves a combination of chemotherapy and immunotherapy. Additionally, hematopoietic stem cell transplantation may be considered in some cases. Surgery is usually not helpful.
Last updated on 05-01-20
Note, these links are external searches against the National Laboratory of Medicine's drug database. You may need to adjust the search if there are no results found.
| Drug Name | Generic Name |
|---|---|
| Calquence | acalabrutinib |
| Brukinsa | zanubrutinib |
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