Mantle cell lymphoma

What causes Mantle cell lymphoma?

Most lymphomas are not inherited, but rather are acquired when the DNA within select body cells has been damaged (somatic DNA damage). Some risk factors for non-Hodgkin lymphomas (NHL) include age (older), gender (male), race (white), and having a condition which weakens the immune system, such as autoimmune conditions, certain genetic disorders, being on immune suppressing medications, HIV/AIDS, HTLV-1, Ebstein-Barr virus, and helicobacter pylori infection.

Last updated on 05-01-20

How is Mantle cell lymphoma diagnosed?

The following tests and procedures may be used to diagnose mantle cell lymphoma:

Physical exam and medical history
Flow cytometry
Bone marrow aspiration or biopsy
Lymph node biopsy (surgical removal of all or part of a lymph node)

If cancer is found, the following tests may be done to study the cancer cells:

Cytogenetic analysis

Last updated on 05-01-20

How might Mantle cell lymphoma be treated?

Treatment of Mantle cell lymphoma (MCL) most often involves a combination of chemotherapy and immunotherapy. Additionally, hematopoietic stem cell transplantation may be considered in some cases. Surgery is usually not helpful.

Last updated on 05-01-20

Name: American Cancer Society 250 Williams Street NW
Atlanta, GA, 30329, United States
Toll Free: 1-800-227-2345 Url:
Name: Lymphoma Research Foundation Wall Street Plaza 88 Pine Street, Suite 2400
New York, NY, 10005, United States
Phone: +1-212-349-2910 Toll Free: 1-800-500-9976 Fax : +1-212-349-2886 Email: Url:
Name: Leukemia and Lymphoma Society 3 International Drive, Suite 200
Rye Brook, NY, 10573, United States
Phone: 1-(888) 557-7177 (general) Toll Free: 1-(800) 955-4572 (patients and families) Email: Url:

Note, these links are external searches against the National Laboratory of Medicine's drug database. You may need to adjust the search if there are no results found.

Drug Name Generic Name
Calquence acalabrutinib
Brukinsa zanubrutinib

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