Malignant mixed Mullerian tumor

Is there a genetic cause of malignant mixed Mullerian tumor?

Presently, most mixed Mullerian tumors (MMMT) are thought to occur by chance without an association to a genetic predisposition. There have been rare reports of MMMT of the uterus developing in individuals with Lynch syndrome, an inherited condition in which individuals have a genetic predisposition to develop certain cancers including uterine cancer. One article in the medical literature describes two cases of MMMT of the ovary in women with personal and family histories of breast cancer, and the authors state that these cases of MMMT of the ovary are suggestive of hereditary breast-ovarian cancer syndrome. As such, these authors state that genetic testing should be considered in women with MMMT of the ovary. Overall, there is currently very little information about the cause of MMMT.

Last updated on 05-01-20

Name: American Cancer Society 250 Williams Street NW
Atlanta, GA, 30329, United States
Toll Free: 1-800-227-2345 Url:
Name: The Gynecological Carcinosarcoma Project GCS Project 2795 Estates Drive
Park City, UT, 84060,
Email: Url:

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