Malignant mixed Mullerian tumor

Presently, most mixed Mullerian tumors (MMMT) are thought to occur by chance without an association to a genetic predisposition. There have been rare reports of MMMT of the uterus developing in individuals with Lynch syndrome, an inherited condition in which individuals have a genetic predisposition to develop certain cancers including uterine cancer. One article in the medical literature describes two cases of MMMT of the ovary in women with personal and family histories of breast cancer, and the authors state that these cases of MMMT of the ovary are suggestive of hereditary breast-ovarian cancer syndrome. As such, these authors state that genetic testing should be considered in women with MMMT of the ovary. Overall, there is currently very little information about the cause of MMMT.