Malignant hyperthermia

Is malignant hyperthermia inherited?

While malignant hyperthermia itself is not inherited, malignant hyperthermia susceptibility (MHS) is inherited in an autosomal dominant manner. This means that having a mutation in only one copy of the responsible gene is enough to make someone susceptible to having malignant hyperthermia.

Most people diagnosed with malignant hyperthermia or MHS have a parent with MHS; however, the parent may not have experienced an episode of malignant hyperthermia. Therefore, the family history may appear to be negative when other family members are susceptible. In some cases, a person with MHS is affected due to having a new (de novo) mutation that was not inherited from a parent. Parents of a person with an apparently new mutation may be evaluated by having contracture testing (a muscle biopsy to determine susceptibility) or molecular genetic testing, if the mutation in the affected person is known.

Each child of a person with MHS has a 50% (1 in 2) risk to inherit MHS.

The risks to siblings of an affected person depend on whether the affected person has a new mutation or inherited MHS from a parent. If a parent has MHS, each sibling as a 50% (1 in 2) risk to have MHS. When both parents appear unaffected based on evaluation, the risk to siblings of an affected person appears to be low.

The risk to other family members of an affected person also depend on whether an affected person's parent has the condition. If a parent also has MHS, other family members are at risk.

People interested in learning about specific genetic risks to themselves or family members should speak with a genetics professional.

Last updated on 05-01-20

Up to what age are individuals able to donate blood?

According to the American Red Cross, to give blood you must be healthy, be at least 17 years old, weigh at least 110 pounds, and not have donated blood in the last 56 days. There is no upper age limit as long as you are well with no restrictions or limitations to your activities. Please visit the American Red Cross Web site at the following link to view further eligibility requirements for blood donation:

Last updated on 05-01-20

Can malignant hyperthermia cause health concerns in daily life or is the condition only triggered by anesthesia?

The vast majority of malignant hyperthermia cases occur during or immediately following anesthesia. However, there is growing evidence that some patients may develop malignant hyperthermia with exercise and/or exposure to hot environments (after heat stroke).

Click here to access additional information related to this topic compiled by the Malignant Hyperthermia Association of America.

Last updated on 05-01-20

How can I find further information on malignant hyperthermia?

If you have further questions on malignant hyperthermia you can contact the Malignant Hyperthermia Association of the United States using the contact information below:

Malignant Hyperthermia Association of the United States (MHAUS)
11 East State St
PO Box 1069
Sherburne, NY 13460
Toll-free (Information line): (800) 986-4287
Telephone: (607) 674-7901
Web site:

You can also find a list of information resources on this topic on our Web site at the following link:

Last updated on 05-01-20

Can people with malignant hyperthermia donate blood? Can malignant hyperthermia be contracted from blood donations?

According to the Malignant Hyperthermia Association of the United States there is no contraindication to blood or organ donation by a person with malignant hyperthermia. Malignant hyperthermia is not "carried" in the blood or organs.

Last updated on 05-01-20

Name: Malignant Hyperthermia Association of the United States (MHAUS) 1 North Main ST PO Box 1069
Sherburne, NY, 13460, United States
Phone: +1-607-674-7901 (none emergency) Toll Free: 1-800-644-9737 (for emergencies, 24 hour) Email: Url: For emergencies outside of North America, call 001-209-417-3722
Name: RYR-1 Foundation P.O. Box 13312
Pittsburgh, PA, 15243,
Phone: 412-529-1482 Email: Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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