Lymphocytic hypophysitis

What causes lymphocytic hypophysitis?

The exact cause of lymphocytic hypophysitis (LH) is still under debate and remains unclear. It has been suggested that LH has an autoimmune etiology. This has generally been supported by the frequent postpartum occurrence and the lymphocytic infiltration, as well as several histopathological, laboratory and clinical findings.

Last updated on 05-01-20

How might lymphocytic hypophysitis be treated?

Lymphocytic hypophysitis can evolve differently among affected individuals, so different treatment strategies may be required. Some individuals experience spontaneous remission (improvement or reversal of the condition without any formal treatment). Careful follow-up is typically recommended.

Many affected individuals only have headaches as a manifesting symptom, and there have been multiple reports of these individuals improving with glucocorticoids alone. Although the use of glucocorticoids or other anti-inflammatory and immunosuppressive drugs have been suggested as medical treatment, their long-term efficacy still needs to be confirmed. High-dose methylprednisolone pulse therapy (short, intensive administration given at set intervals) seems to be effective in about 30% of treated patients.

Transsphenoidal surgery (accessed "through the nose") to confirm diagnosis and save viable pituitary tissue may be required in individuals with symptoms or signs of severe compression. Visual improvement following decompression with this type of surgery has been reported. In some cases, pituitary biopsy is both diagnostic and therapeutic, because after this procedure a progressive recovery of pituitary function may occur.

Last updated on 05-01-20

Name: The Pituitary Foundation 86 Colston Street Bristol BS1 5BB
United Kingdom
Phone: 0117 370 1320 Email: helpline@pituitary.org.uk Url: https://www.pituitary.org.uk/
Name: The Endocrine Society 8401 Connecticut Avenue, Suite 900
Chevy Chase, MD, 20815, United States
Phone: 301–941–0200 Toll Free: 888–363–6274 Fax : 301–941–0259 Email: societyservices@endo-society.org Url: http://www.endo-society.org
Name: Hypophysitis Research Center Johns Hopkins Schools of Medicine & Public Health Ross Bldg. Room 660
720 Rutland Avenue
Baltimore, MD, 21205,
Phone: +1-443-287-4593 Fax : +1-410-614-3548 Email: pcat@jhmi.edu Url: http://pathology.jhu.edu/hypophysitis/

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