Lucey-Driscoll syndrome

What causes Lucey-Driscoll syndrome?

Lucey-Driscoll syndrome is caused by a substance in the blood that limits the ability of bilirubin to be removed by the body. This leads to the build-up of very high levels of bilirubin that may be toxic to the brain and other organs. Inherited cases may result from the pregnant woman having a gene change (mutation) in the uridine diphosphate-glucuronosyltransferase gene( UGT1A1 ). This gene mutation may increase the chance of a baby having Lucey-Driscoll syndrome.

Last updated on 05-01-20

Memon N, Weinberger BI, Hegyi T, Aleksunes LM,. Inherited disorders of bilirubin clearance Pediatr Res. Mar 2016; 79(3). 378-386. Reference Link Erlinger S, Arias IM, Dhumeaux D. Inherited disorders of bilirubin transport and conjugation: new insights into molecular mechanisms and consequences Gastroenterology. Jun 2014; 146(7). 1625-1638. Reference Link

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