Livedoid vasculopathy

How might livedoid vasculopathy be treated?

Treatment of livedoid vasculopathy aims to reduce pain, ulceration and scarring. General treatment measures may involve protecting the skin from injury and irritants, removing dead tissue from the ulcers, treating infection with antibiotics, elevating legs, compression therapy, and avoiding smoking and hormonal contraceptives. Treatments will also be given to address any co-occurring conditions such as lupus or thrombophilia. Drugs that aim to improve blood flow or prevent blood clotting may also be considered. Examples of these treatments, include:

Antiplatelet agents (e.g. aspirin, dipyridamole)
Fibrinolytic agents (e.g. danazol, tissue plasminogen activator)
Anticoagulant agents (e.g. subcutaneous heparin injections, oral warfarin)
Pentoxifylline
Low-dose danazol (200 mg/day orally)
Hyperbaric oxygen
Pulsed intravenous immunoglobulin
Iloprost
Ketanserin
Psoralen plus ultraviolet A (PUVA) therapy
Niacin (nicotinic acid)
Sulfapyridine
Guanethidine

Currently there are no established guidelines for treatment. Decisions for treatment are made based on the clinicians clinical experience and specific patient characteristics. We strongly recommend that you discuss this information and your treatment options further with a trusted healthcare professional.

Last updated on 05-01-20

Selected Full-Text Journal Articles

Free full text articles on Livedoid vasculopathy

Hairston BR et al., Livedoid Vasculopathy: Further Evidence for Procoagulant Pathogenesis. Arch Dermatol. 2006;142(11):1413-1418.

Last updated on 04-27-20


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