Lipoid proteinosis of Urbach and Wiethe

What is the long-term outlook for people with lipoid proteinosis of Urbach and Wiethe?

The long-term outlook for people with lipoid proteinosis (LP) of Urbach and Wiethe is usually good. The life expectancy is generally normal, although throat obstructions, upper respiratory infections and/or severe seizures can be fatal in rare cases. Depending on the severity of symptoms, LP may strongly impact quality of life.

Last updated on 05-01-20

How might lipoid proteinosis of Urbach and Wiethe be treated?

There is currently no cure for lipoid proteinosis (LP) of Urbach and Wiethe. Treatment is based on the signs and symptoms present in each person. The skin abnormalities found in people affected by LP may be treated with certain medications, including corticosteriods, dimethyl sulfoxide; or d-penicillamine. An additional medication called acitretin can be used to treat hoarseness and some skin problems. Anticonvulsant medications are often prescribed for people with seizures. The success of these medications in treating the signs and symptoms of LP varies.

Affected people with growths on their vocal cords or eyelids may be treated with carbon dioxide laser surgery. Dermabrasion (removal of the top layer of skin) may also improve the appearance of skin abnormalities.

Last updated on 05-01-20


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