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Light chain deposition disease (LCDD) is a rare condition characterized by the deposition of specific proteins (monoclonal light chains) in the kidneys and other organs. Light chains are used to make antibodies that the body needs to fight infection. People with LCDD make too many light chains, which get deposited in many body tissues. While LCDD can occur in any organ, the kidneys are always involved. Signs and symptoms of LCDD may include protein in the urine; decreased kidney function; and/or nephrotic syndrome. Rarely, a person with LCDD may have symptoms from cardiac (heart) or liver involvement.
The underlying cause of LCDD is unknown. It is often associated with multiple myeloma. LCDD may progress to multiple myeloma, or it may be present with multiple myeloma when it is first diagnosed.
The goal of treating LCDD is to slow the production of light chains and their damage to organs. Treatment may include chemotherapy with a drug called Bortezomib; autologous stem cell transplantation; immunomodulatory drugs; and/or kidney transplant. If untreated, end-stage renal disease occurs in 70% of cases.
Source: GARD Last updated on 05-01-20
Technically, light chain deposition disease (LCDD) is not considered a cancer. However, it shares some characteristics with cancer, and can be associated with certain types of cancer.
LCDD is a clonal plasma cell proliferative disorder in which fragments of light chains (parts of antibodies made by plasma cells) multiply uncontrollably and deposit in tissues of the body. In cancer, specific types of entire cells multiply, and may spread into surrounding tissues. Like cancer, the process occurring in LCDD is difficult to stop or slow down, and can ultimately lead to organ damage and failure.
LCDD is associated with multiple myeloma in many cases. Multiple myeloma is a cancer due to malignant plasma cells, which are the same type of cells involved in LCDD. A person may first have LCDD and then develop multiple myeloma, or they may both be found to be present when a person is first diagnosed. LCDD can also be associated with lymphoma.
Last updated on 05-01-20
The International Multiple Myeloma Foundation offers information on light chain deposition disease on their Web site. Click on the link above to view the information page.
Last updated on 04-27-20
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