Lewis-Sumner syndrome

What is the cause of Lewis-Sumner syndrome?

Lewis-Sumner syndrome is an acquired condition, meaning that the symptoms of the disease are not present at birth. The disease is not believed to be genetic, meaning that it is not known to be caused by changes (mutations) to our genes. In some cases, Lewis-Sumner syndrome is a side-effect of a type of medication called antagonists of TNF-alpha (anti- TNFα) This type of medication may be used for treatment of arthritis and inflammatory bowel disease.

Last updated on 05-01-20

How is Lewis-Sumner syndrome diagnosed?

The diagnosis of Lewis-Sumner syndrome consists of a clinical evaluation showing symptoms of Lewis-Sumner disease, as well as nerve conduction studies showing the involvement of the nerves leading to the upper limbs. Nerve conduction studies use electrical stimulation to measure how well the nerves are working. The diagnosis can be confirmed by performing a specific type of imaging test called MRI T2 STIR. This imaging technique allows for clearer viewing of the brachial plexus, which is one of the nerve networks that is often affected by Lewis-Sumner syndrome.

Last updated on 05-01-20

What is the treatment for Lewis-Sumner syndrome?

The treatment most commonly used for Lewis-Sumner syndrome is intravenous immunoglobulins (IVIg). This type of therapy uses a mixture of antibodies delivered through an IV to help alleviate the symptoms of the disease, and is successful in 80% of cases. For individuals who do not respond to IVIg, treatment with subcutaneous immunoglobulins or plasma exchange have proved effective. Up to 40% of individuals who are not responsive to treatment eventually experience a reduction in symptoms.

Last updated on 05-01-20

Name: GBS/CIDP Foundation International 375 East Elm Street, Suite 101
Conshohocken, PA, 19428, United States
Phone: +1-610-667-0131 Toll Free: 1-866-224-3301 (from North America) Fax : +1-610-667-7036 Email: info@gbs-cidp.org Url: https://www.gbs-cidp.org/

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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