Kyrle disease

What causes Kyrle disease?

The cause of Kyrle disease is currently unknown. However, it appears to occur more frequently in patients with certain conditions such as diabetes mellitus, kidney disease, liver abnormalities, and congestive heart failure.

In some families, the condition appears to be inherited but an underlying genetic cause has not been identified.

Last updated on 05-01-20

How is Kyrle disease diagnosed?

A diagnosis of Kyrle disease is often suspected based on the presence of characteristic signs and symptoms on physical examination. The deep penetration of the keratin plugs, the size and irregularity of the papules, the age of onset and the location of the skin lesions can help differentiate Kyrle disease from other conditions that are associated with similar skin findings. A workup for Kyrle disease should also include an evaluation for any underlying diseases that can be associated with the condition.

Last updated on 05-01-20

Is Kyrle disease inherited?

Many cases of Kyrle disease occur sporadically in people with no family history of the condition. In these affected people, the condition may be idiopathic (of unknown cause) or associated with a condition such as diabetes mellitus, kidney disease, liver abnormalities, and congestive heart failure.

In some families, Kyrle disease does appear to be inherited. Although the underlying genetic cause has not been identified, some studies suggest that the condition may follow an autosomal recessive pattern in these families.

Last updated on 05-01-20

How might Kyrle disease be treated?

Kyrle disease is most often associated with conditions such as diabetes mellitus, kidney disease, liver abnormalities and congestive heart failure. Therefore, treatment is typically directed toward the underlying condition when appropriate. Rapid improvement and resolution of the lesions is often seen once the associated condition is treated.

Other treatment options specifically target the signs and symptoms associated with Kyrle disease. For example, medicated lotions, sedating antihistamines, and topical corticosteroids may be prescribed in people with severe itching. UV light therapy is reportedly particularly helpful for people with widespread lesions or severe itching from renal or hepatic disease. Carbon dioxide laser or cryosurgery may be helpful for some people with a few lesions.

Last updated on 05-01-20

Name: American Academy of Dermatology 1445 New York Ave, NW Suite 800
Washington, DC, 20005, United States
Toll Free: 888-462-DERM (3376) Fax : 847-240-1859 Email: Url:
Name: American Association of Kidney Patients 3505 E. Frontage Rd., Suite 315
Tampa, FL, 33607-1796, United States
Phone: 813-636-8100 Toll Free: 800-749-2257 Fax : 813-636-8122 Email: Url:

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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