Juvenile amyotrophic lateral sclerosis

What causes juvenile amyotrophic lateral sclerosis?

Juvenile amyotrophic lateral sclerosis (JALS) can be caused by mutations in any of several genes including ALS2 , SIGMAR1 , SPG11 , SETX , SOD1 , UBQLN2 , FUS, _and TARDBP_. Mutations bay be inherited from a parent or occur for the first time in a person with the disease. Inheritance may be autosomal recessive or autosomal dominant depending on the gene involved.

Genes responsible for amyotrophic lateral sclerosis (ALS) are important for normal functioning of motor neurons and other cells. It isn't always clear how mutations in these genes cause ALS.

Last updated on 05-01-20

How might juvenile amyotrophic lateral sclerosis be treated?

There is no specific treatment for juvenile amyotrophic lateral sclerosis (JALS). Management generally involves strategies to to relieve symptoms and to promote mobility and independence. Medications may include those for specific symptoms such as fatigue and muscle cramping. Physical therapy and special equipment can be helpful. Multidisciplinary teams of various health care professionals can help to develop personalized treatment plans.

Last updated on 05-01-20

Name: Muscular Dystrophy Association - ALS Division 3300 East Sunrise Drive Amyotrophic Lateral Sclerosis
Tucson, AZ, 85718-3208, United States
Phone: 800-572-1717 or 800-344-4863 Fax : 520-529-5300 Email: mda@mdausa.org Url: https://www.mda.org/disease/amyotrophic-lateral-sclerosis
Name: Amyotrophic Lateral Sclerosis Society of Canada 265 Yorkland Boulevard Suite 300
Toronto Ontario M2J 1S5
Phone: 800-267-4ALS (800-267-4257) Fax : 416-497-1256 Email: SI@als.ca Url: http://www.als.ca
Name: The ALS Association 1275 K Street, N.W. Suite 250
Washington, DC, 20005,
Phone: 202-407-8580 Toll Free: 1-800-782-4747 Fax : 202-464-8869 Email: alsinfo@alsa-national.org Url: http://www.alsa.org

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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