Isolated levocardia

Has MRI or other tests been helpful in planning the care of infants prenatally diagnosed with isolated levocardia?

Yes. In isolated levocardia it can be difficult to determine the position of the internal organs. Ultrasonography, CT, and MRI have been used alone and in combination to improve imaging of the internal organs and major blood vessels.

In addition, a careful assessment of the spleen in the newborn is important. People with spleen dysfunction are at an increased risk for serious infection and benefit from prophylactic life-long antibiotics and vaccination. Barium contrast screening has been used for early detection of intestinal malrotation and to guide treatment. Also, long-term, infrequent follow-up of infants and adults with isoalted levocardia to monitor for heart rhythm problems is recommended.

Last updated on 05-01-20

What is isolated levocardia?

Isolated levocardia is a type of situs inversus where the heart is located in the normal position, but there is a mirror-image reversal of other internal organs. Isolated levocardia may occur alone or with heart defects, heart rhythm abnormalities (sick sinus syndrome or atrioventricular node disorder), spleen defects (absent, underdeveloped, or extra spleen), and intestinal malrotation. Long term outlook varies depending on the presence/absence of associated abnormalities, particularly heart defects. The cause of isolated levocardia is not known. It is not usually associated with chromosome abnormalities.

Last updated on 05-01-20

Have there been other cases of prenatally diagnosed isolated levocardia?

The actual prevalence of prenatally diagnosed cases of isolated levocardia is not known. Our search of the medical literature identified nine published cases.

Last updated on 05-01-20

Are there any support resources for isolated levocardia?

While we could not find a support resource specifically for families with a child with isolated levocardia, there are a number of organizations that provide information, networking opportunities, and support to families with a child with a heart condition. You can view these groups on our **** Web site at the following link: levocardia/resources/5

Last updated on 05-01-20

What is the long-term outlook of infants prenatally diagnosed with isolated levocardia?

The overall outlook for infants born with isolated levocardia will vary depending largely on the absence/presence of heart defects. You can find grim estimates for long term survival in dated literature (published in the 1960’s and 70’s). These statistics do not account for mild cases of isolated levocardia diagnosed as a result of improved technologies and detection.

Last updated on 05-01-20

Selected Full-Text Journal Articles

Isolated Levocardia Gindes et al., 2007

Gindes L, Hegesh J, Barkai G, Jacobson JM, Achiron R. Isolated levocardia: prenatal diagnosis, clinical importance, and literature review. J Ultrasound Med. 2007 Mar;26(3):361-5.

Last updated on 04-27-20

Name: American Heart Association 7272 Greenville Avenue
Dallas, TX, 75231-4596, United States
Phone: 214-570-5978 Toll Free: 800-242-8721 Email: Url:
Name: Mended Hearts, Inc. 8150 N. Central Expressway, M2248
Dallas, TX, 75206, United States
Phone: 214-206-9259 Toll Free: 888-HEART99 Fax : 214-295-9552 Email: Url:
Name: Sidelines High Risk Pregnancy Support P. O. Box 1808
Laguna Beach, CA, 92652, United States
Toll Free: (888)447-4754 (HI-RISK4) Email: Url:
Name: The Children's Heart Foundation PO Box 244
Lincolnshire, IL, 60069-0244, United States
Phone: 847-634-6474 Toll Free: 888-248-8140 Email: Url:

Connect with other users with Isolated levocardia on the RareGuru app

Do you have information about a disease, disorder, or syndrome? Want to suggest a symptom?
Please send suggestions to RareGuru!

The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

People Using the App

Join the RareGuru Community

To connect, share, empower and heal today.

People Using the App