Iron-refractory iron deficiency anemia

What is the long-term outlook for people with iron-refractory iron deficiency anemia?

Children with IRIDA typically have normal growth and development. While information regarding the long- term effects of IRIDA are limited, in general, signs and symptoms of IRIDA appear to improve with age.

Last updated on 05-01-20

How might iron-refractory iron deficiency anemia be treated?

Children with iron-refractory iron deficiency anemia (IRIDA) usually do not respond to oral iron therapy. However, some children with IRIDA may partially respond to high doses of oral iron, prolonged oral iron therapy, or oral iron therapy combined with vitamin C. Medical researchers suggest the different responses to iron therapies may be linked to the exact change or mutation in the TMPRSS6 gene causing IRIDA.

Current treatment guidelines recommend an initial trial of oral iron along with vitamin C for several weeks to see if the anemia improves. If there is no improvement or minimal improvement, further treatment involves intravenous (IV) iron therapy. Even with IV therapy, only a partial improvement is expected. However in most cases, partial improvement of mild to moderate anemia results in enough healthy red blood cells to provide all of the body with oxygen. In addition, although only a few people with IRIDA have been followed into adulthood, red blood cell levels have been found to increase to low normal levels, suggesting treatment of adults with IRIDA may not be needed.

Last updated on 05-01-20

Connect with other users with Iron-refractory iron deficiency anemia on the RareGuru app

Do you have information about a disease, disorder, or syndrome? Want to suggest a symptom?
Please send suggestions to RareGuru!

The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

People Using the App

Join the RareGuru Community

To connect, share, empower and heal today.

People Using the App