Inflammatory linear verrucous epidermal nevus

What is inflammatory linear verrucous epidermal nevus?

Inflammatory linear verrucous epidermal nevus (ILVEN) is a type of skin overgrowth, called epidermal nevus. It is characterized by skin colored, brown, or reddish, wart-like papules (nevi). The nevi join to form patches or plaques that often follow a pattern on the skin known as the "lines of Blaschko". The affected areas of the skin may be red, itchy, and inflamed. ILVEN typically presents from birth to early childhood and often is limited to one side of the lower half of the body. It affects females more often than males. It usually occurs alone; however, rarely ILVEN can be associated with other symptoms as part of an epidermal nevus syndrome. Rarely, ILVEN can become cancerous (for example, basal cell carcinoma or squamous cell carcinoma).

ILVEN is caused by a genetic change that occurs after conception (somatic mutation). How this alteration leads to the signs and symptoms of ILVEN is not well understood. There is no one treatment or cure for ILVEN. Products used to soften the skin (emollients), moisturizers, and topical steroids may be utilized to relieve symptoms of dryness and itching. Recently, several patients have been treated with laser therapy with good results.

Last updated on 05-01-20

Is inflammatory linear verrucous epidermal nevus (ILVEN) genetic? Can a mother with ILVEN pass this condition to her child?

Most often inflammatory linear verrucous epidermal nevus (ILVEN) occurs sporadically for the first time in a family in the affected individual. It is likely due to a random gene mutation that occurred in the individual's skin cells while he/she was developing in his/her mother's womb. Future offspring and other family members are usually not affected, however there have been rare reports of ILVEN occurring in more than one member of the same family.

Insuring an accurate diagnosis is important in determining your risk to future offspring. There is a rare skin condition called epidermolytic epidermal naevus, where a parent with epidermal nevi, has gone on to have a child with more extensive or generalized disease. We are not aware of a similar case report for individuals with ILVEN. Certain epidermal nevus syndromes may also be associated with an increased risk to offspring. To learn more about your specific risk to future offspring, we recommend that you consult with a genetics professional. Genetics clinics are a source of information for individuals and families regarding diagnosis, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference at

To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:

Last updated on 05-01-20

Selected Full-Text Journal Articles

verrucous nevus

Kossan, Meredith K, Inflammatory linear verrucous epidermal nevus, Dermatology Online Journal 9(4): 15, 2003

Last updated on 04-27-20

Name: Nevus Outreach, Inc. 600 SE Delaware Ave., Suite 200
Bartlesville, OK, 74003, United States
Phone: +1-918-331-0595 Email: Url:

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