Ichthyosis vulgaris

What causes ichthyosis vulgaris?

Ichthyosis vulgaris is caused by a genetic mutation. The mutated gene causes an abnormality in the normal lifecycle of skin. Whilst in most people, the growth, dying and shedding of skin happens unnoticed, people with ichthyosis reproduce new skin cells at a rate faster than they can shed it, or reproduce at a normal rate but the rate of shedding is too slow. Either way there is a build up of dry scaly skin. The mutated gene in ichthyosis vulgaris is found on chromosome 1q21 and is related to a protein called filaggrin. To learn more about the protein filaggrin please click here.

Last updated on 05-01-20

How might ichthyosis vulgaris be treated?

While there's no known cure for ichthyosis, there are treatments available to help manage the symptoms. Medications may include:

  1. Creams and ointments containing alpha hydroxy acids such as lactic acid and glycolic acid that help to control scaling of the skin and increase skin moisture.
  2. Retinoids to reduce the production of skin cells.
  3. Antibiotics to treat secondary infections.

Last updated on 05-01-20

Name: Foundation for Ichthyosis and Related Skin Types FIRST 2616 North Broad Street
Colmar, PA, 18915 , United States
Phone: +1-215-997-9400 Toll Free: 1-800-545-3286 Email: info@firstskinfoundation.org Url: http://www.firstskinfoundation.org/

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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