Hypothalamic obesity

What causes hypothalamic obesity?

Hypothalamic obesity is caused by injury to the hypothalamus. The most common cause is related to a rare non-cancerous tumor called a craniopharyngioma. When this tumor is removed, the hypothalamus can get damaged leading to the symptoms of hypothalamic obesity. Other causes for hypothalamic obesity include other rare tumors, head trauma, swelling in the brain and being born with a brain malformation. Certain genetic syndromes also include symptoms of hypothalamic obesity.

Last updated on 05-01-20

How might hypothalamic obesity be diagnosed?

The diagnosis of hypothalamic obesity is made based on the symptoms which include a sudden onset of excessive hunger and weight gain after trauma or brain surgery. Testing for specific hormone levels can also help with diagnosis and guide treatment.

Last updated on 05-01-20

How is hypothalamic obesity inherited in families?

Hypothalamic obesity is usually an acquired condition and is not inherited in families. There are a few rare genetic inherited conditions that include the symptoms of hypothalamic obesity such as Bardet-Biedl syndrome and leptin deficiency. Prader-Willi syndrome also shares symptoms with hypothalamic obesity, but it is not generally inherited in families.

Last updated on 05-01-20

What is the long-term outlook for people with hypothalamic obesity?

The long-term outlook for people with hypothalamic obesity depends on the cause of the condition and how well weight can be managed. Severe obesity can lead to complications such as diabetes, heart disease, and stroke.

Last updated on 05-01-20

How many people have hypothalamic obesity?

The number of people with hypothalamic obesity is unknown. Craniopharyngiomas, the most common cause of this condition, are very rare and occur in about 1.3 per million people.

Last updated on 05-01-20

How might hypothalamic obesity be treated?

There is not one specific treatment for hypothalamic obesity. The goal of treatment in general is to promote weight loss and control hunger. Most people with this condition are treated with a combination of gastric surgery, medications, and nutritional and lifestyle counseling.

Many of the medications used to treat hypothalamic obesity are also used to treat type 2 diabetes. These include metformin, octreotide, and GLP1 receptor agonists. Other medications include stimulants and hormonal treatments. Nutritional and lifestyle counseling can also help with weight management.

Last updated on 05-01-20

Name: Hormone Health Network United States Toll Free: 1-800-HORMONE (1-800-467-6663) Email: hormone@endocrine.org Url: https://www.hormone.org
Name: The Pituitary Foundation 86 Colston Street Bristol BS1 5BB
United Kingdom
Phone: 0117 370 1320 Email: helpline@pituitary.org.uk Url: https://www.pituitary.org.uk/
Froelich syndrome National Organization for Rare Disorders (NORD). 2004; Reference Link Bereket A, Kiess W, Lustig RH, Muller HL, et al. Hypothalamic obesity in children Obes Rev. Sept 2012; 13(9). 780-98. Reference Link Haliloglu B, Bereket A. Hypothalamic obesity in children: pathophysiology to clinical management J Pediatr Endocrin Metab. May 2015; 28(5-6). 503-13. Reference Link

Connect with other users with Hypothalamic obesity on the RareGuru app

Do you have information about a disease, disorder, or syndrome? Want to suggest a symptom?
Please send suggestions to RareGuru!

The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

People Using the App

Join the RareGuru Community

To connect, share, empower and heal today.

People Using the App