Hydatidiform mole

Might DICER1 syndrome play a role in male infertility or molar pregnancy?

It is possible that DICER1 mutations affect male fertility, however studies in this area are very preliminary. In mice, it has been shown that the deletion of the DICER1 gene or inactivation of the Dicer protein affect sperm production, resulting in absent, decreased amounts, or abnormal sperm.

We did not find information in our search regarding an association between DICER1 gene mutations and molar pregnancy specifically. "Partial" molar pregnancies can be caused by fertilization by an abnormal sperm (one with two copies of chromosomes). It can also be caused by fertilization with two normal sperm.

"Complete" molar pregnancies are thought to occur when the mother's chromosomes are lost and the father's chromosomes are duplicated. Complete molar pregnancy can also occur if the egg has no nucleus (the part of the cell that holds the chromosomes) or an inactive nucleus.

You can learn more about molar pregnancy through the following Web sites:

Hydatidiform mole (MedlinePlus.gov)
Molar Pregnancy (Mayo Foundation for Medical Education and Research)
Hydatidiform Mole (The Merck Manual)

Last updated on 05-01-20

If one is concerned about having another molar pregnancy, who might one speak to?

If you are concerned about your chances of having another molar pregnancy, we recommend you speak with your health care provider.

Last updated on 05-01-20

If one has had a molar pregnancy, what is the possibility of having future molar pregnancies?

Although we cannot provide specific risks, the literature states that the majority of women who become pregnant after a molar pregnancy will not have another molar pregnancy. In general, the risk of a repeat mole in a subsequent pregnancy is about 1 in 60.

Last updated on 05-01-20

What is molar pregnancy?

Molar pregnancy is a condition in which the placenta does not develop properly. The symptoms of molar pregnancy, which may include vaginal bleeding, severe morning sickness, stomach cramps, and high blood pressure, typically begin around the 10th week of pregnancy. Because the embryo does not form or is malformed in molar pregnancies, and because there is a small risk of developing a cancer called choriocarcinoma, a D&C is usually performed.

Last updated on 05-01-20

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