Hereditary antithrombin deficiency

What is the prognosis for individuals with hereditary antithrombin deficiency?

The prognosis depends on the degree of antithrombin deficiency, the nature of the clots formed, and the number of clots formed. Patients with recurring clots are more likely to suffer a life-threatening clotting event in the future and are best treated with indefinite Warfarin therapy.

Last updated on 05-01-20

How might hereditary antithrombin deficiency be treated?

Once a patient with hereditary antithrombin deficiency develops a clot, anticoagulation therapy (usually Warfarin) is often indicated. The duration of therapy after a first clot, especially in children, is a matter of some controversy, but therapy is generally continued for 3-6 months. Individuals who experience a second clot are at a significant risk for future clotting and are candidates for long-term Warfarin therapy. Asymptomatic individuals are often not treated with anticoagulation therapy. Should surgery be necessary, individuals with hereditary antithrombin deficiency may receive antithrombin III concentrate or fresh frozen plasma to boost antithrombin levels.

Last updated on 05-01-20

Name: National Blood Clot Alliance 8321 Old Courthouse Road Suite 255
Vienna, VA, 22182, United States
Phone: +1-703-935-8845 Toll Free: 1-877-466-2568 (877-4NO-CLOT) Email: Url:
Name: Clot Connect UNC Hemophilia and Thrombosis Center 6340 Quadrangle Drive, Suite 50
Chapel Hill, NC, 27517, United States
Email: Url:
Mitton BA. Antithrombin Deficiency Medscape Reference. October 24, 2014; Reference Link

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The RareGuru disease database is regularly updated using data generously provided by GARD, the United States Genetic and Rare Disease Information Center.

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